Efficacy of Stromal Vascular Fraction on Acne Scar Correction
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19-45
SponsorSeoul National University Hospital
About this trial
This study aims to evaluate the efficacy and safety of intradermal injection of autologous stromal vascular fraction (SVF) in the treatment of atrophic acne scars. SVF is a heterogeneous cell population derived from adipose tissue, containing various regenerative and immunomodulatory cells, including mesenchymal stem cells, endothelial progenitor cells, and pericytes.
In this prospective, randomized, split-face clinical trial, participants with atrophic acne scars will receive SVF injections on one side of the face and normal saline (NS) injections on the contralateral side as a control. Clinical efficacy will be assessed through blinded scar counts, digital imaging, and histological evaluations including epidermal and dermal regenerative markers. The study is designed to investigate whether SVF provides superior clinical improvement compared to placebo.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age between 19 and 45 years
Presence of bilateral atrophic acne scars (boxcar, rolling, or icepick types) on the face
Willingness to undergo fat harvesting procedure
Ability to comply with study visits and follow-up
Disqualifiers
Active acne lesions on the treatment area
History of keloid or hypertrophic scarring
Prior treatment for acne scars (e.g., laser, filler, microneedling) within the past 6 months
History of systemic immunosuppressive therapy within the past 3 months
Trial design
Design model
Crossover
Treatments tested in this trial
stromal vascular fraction (SVF)
Biological/VaccineAutologous stromal vascular fraction (SVF) isolated from adipose tissue was injected intradermally into one side of the face to evaluate its efficacy in treating atrophic acne scars. SVF was freshly prepared on the same day of injection using enzymatic digestion and centrifugation.
Normal Saline (NS)
Other interventionNormal saline (NS) was injected intradermally into the contralateral side of the face and served as a placebo comparator to SVF in this split-face study on atrophic acne scars.
Treatment groups
16 Participants
are divided into 2 treatment groupsGroup A: SVF-treated sideExperimental treatment 1 intervention
Group B: Saline-treated sidePlacebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Change in total number of atrophic acne scars from baseline to Week 5
Time frame
Baseline and 5 weeks after treatment2
Change in total number of atrophic acne scars from baseline to Week 10
Time frame
Baseline and 10 weeks after treatmentLocations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: