Health TrialsbyHealthPanel

Egg Intake, Metabolic Outcomes and Choline Levels

ConditionObesity and Obesity-related Medical Conditions
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age30-65
SponsorUniversity of Guelph

About this trial

The purpose of this research is to determine the effect of additional daily egg intake on metabolic phenotypes and metabolism in the context of obesity.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Male or female participant of any race or ethnicity between 30-65 (inclusive) years of age

BMI > 30 kg/m2

Non-smoker

Willing to consume 3 eggs per day for one dietary period of 4 weeks

Disqualifiers

Age < 30 or > 65 years

BMI < 30 kg/m2

Vegans or individuals who do not consume eggs

Individuals who are currently pregnant or planning to become pregnant during the course of the study; or are currently breastfeeding

Trial design

Design model

Single group

Treatments tested in this trial

  • 3 whole eggs

    Dietary supplement

    Participants will be free-living and will not be supplied with any other food except for the eggs during the intervention period with no restrictions of energy intake.

Treatment groups

20 Participants
are divided into 1 treatment group
Group A: 4 weeks of additional daily intake of 3 whole eggsExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Liver physical density by imaging technologies

Time frame
Weeks 0, 4, 8 and 12
2

Liver morphology as assessed by imaging technologies

Time frame
Weeks 0, 4, 8 and 12
3

Concentration of circulating liver enzymes

Time frame
Weeks 0, 4, 8 and 12
4

Concentration of circulating lipid markers

Time frame
Weeks 0, 4, 8 and 12

Secondary outcomes

1

Choline metabolite response

Time frame
Weeks 0, 4, 8 and 12
2

Trimethylamine-N-oxide metabolite response

Time frame
Weeks 0, 4, 8 and 12
3

Flavin monooxygenase 3 (FMO3) 472 G>A genetic polymorphism

Time frame
Week 0
4

Composition of fecal microbiota

Time frame
Weeks 0, 4, 8 and 12

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Guelph

Lead sponsor

Institut universitaire de cardiologie et de pneumologie de Québec, University Laval

Collaborator

Source ClinicalTrials.gov
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