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EIT-Guided Ventilator Settings in AHRF

ConditionsAcute Hypoxemic Respiratory FailureAcute Respiratory Distress Syndrome (ARDS)Mechanical PowerVentilator Induced Lung InjuryElectrical Impedance Tomography (EIT)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorMahidol University

About this trial

This exploratory study aims to investigate the effect of Electrical Impedance Tomography (EIT)-guided ventilator settings on mechanical power in patients with acute hypoxemic respiratory failure (AHRF), including both ARDS and non-ARDS conditions. Mechanical power, a key factor associated with ventilator-induced lung injury (VILI), will be measured before and after EIT-guided PEEP titration. The study will evaluate feasibility and changes in lung mechanics, gas exchange, and EIT parameters. A total of 17 patients requiring invasive mechanical ventilation will be enrolled at Siriraj Hospital, Mahidol University.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 18 years

Diagnosed with acute hypoxemic respiratory failure within 48 hours

Expected to require invasive mechanical ventilation ≥ 48 hours

On mechanical ventilation within 24 hours

Disqualifiers

Pregnancy

Body mass index (BMI) > 40 kg/m2

Contraindications to using electrical impedance tomography, including

Presence of a pacemaker or automatic implantable cardioverter-defibrillator (AICD)

Trial design

Design model

Single group

Treatments tested in this trial

  • Electrical Impedance Tomography (EIT), Enlight 2100

    Device

    Patients will undergo ventilator adjustments using EIT-guided PEEP titration to optimize mechanical power and lung mechanics.

Treatment groups

17 Participants
are divided into 1 treatment group
Group A: EIT-guided PEEP titrationExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change in Mechanical Power

Mechanical power (MP) will be calculated using Gattinoni's simplified formula. Simplified Gattinoni's formula: MP = 0.098 × respiratory rate × tidal volume × \[peak inspiratory pressure - (plateau pressure - PEEP)/2\] calculated mechanical power (measured in J/min) before and after using EIT-guided PEEP titration in patients with acute hypoxemic respiratory failure. Unit of Measure: Joules per minute (J/min)

Time frame
ฺBaseline and 2 hours after EIT-guided ventilator adjustment and follow-up over 24 hours (baseline, 2 hours, 12 hours, and 24 hours after EIT-guided ventilator adjustment)

Secondary outcomes

1

Change in PEEP level

Positive End-Expiratory Pressure (PEEP) level before and after EIT-guided ventilator adjustment. Unit of Measure: cmH₂O

Time frame
At baseline and then 2 hours, 12 hours, 24 hours after EIT-guided PEEP titration
2

Change in Respiratory Static Compliance

calculate static respiratory compliance (tidal volume/driving pressure) before and after EIT-guided PEEP titration Unit of Measure: mL/cmH₂O

Time frame
Baseline, 2 hours, 12 hours, and 24 hours after intervention
3

Change in Driving Pressure

calculate driving pressure (plateau pressure - PEEP) following EIT-guided PEEP titration. Unit of Measure: cmH₂O

Time frame
Baseline, 2 hours, 12 hours, and 24 hours after intervention
4

Change in Plateau Pressure

measure plateau pressure before and after EIT-guided PEEP titration.

Time frame
Baseline, 2 hours, 12 hours, and 24 hours after intervention

Other outcomes

Sponsors and contacts

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Mahidol University

Lead sponsor

Source ClinicalTrials.gov
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