Health TrialsbyHealthPanel

Electrical Impedance Tomography-Based Prognostic Model for ARDS

ConditionsAcute Respiratory Distress Syndrome (ARDS)Ventilator-induced Lung Injury
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorXiaoJing Zou,MD

About this trial

This multicenter, prospective, observational study aims to develop and validate an EIT-based prognostic model for ARDS. By focusing on the pathophysiological characteristics of ARDS and the causes of ventilator-induced lung injury, the investigators intend to establish a prognostic model that reveals lung injury and heterogeneity, enabling risk stratification and guiding individualized treatment.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Meet the new 2023 ARDS global definition;

Age 18-80 years

Disqualifiers

Expected death within 24 hours of screening;

Metastatic cancer (active malignancy with distant metastases);

Severe psychiatric disorders;

Pregnancy or postpartum status;

Trial population

This is a prospective, multicenter, observational cohort study that will enroll adult patients (aged 18-80 years) diagnosed with acute respiratory distress syndrome (ARDS) per the new 2023 ARDS global definition.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Not applicable- observational study

    Other intervention

    Not applicable- observational study

Treatment groups

625 Participants
are divided into 2 treatment groups
Group A: ARDS Patients for Training cohort1 intervention
Group B: ARDS Patients for Validation cohort1 intervention

Trial outcomes

Primary outcomes

1

28-day mortality rate

Time frame
From date of study enrollment (Day 0) until Day 28

Secondary outcomes

1

ICU mortality rate

Time frame
From ICU admission to discharge, up to 24 weeks
2

60-day all-cause mortality rate

Time frame
60 days post-enrollment
3

90-day all-cause mortality rate

Time frame
90 days post-enrollment
4

Duration of mechanical ventilation (days)

Time frame
From intubation to successful extubation, up to 28 days

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

XiaoJing Zou,MD

Lead sponsor

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sponsor institution

Source ClinicalTrials.gov
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