The objective of this study is to examine if calcium and vitamin D supplements and/or prune can prevent bone loss in postmenopausal women.
Postmenopausal
BMD t-score is between 0.5 and 2 SD below the mean
Not on hormone replacement therapy (HRT) and/or other pharmacological agents known to affect bone for at least three months prior to initiation of the study
Women whose BMD t-score at any site falls below 2.5 SD of the mean
Subjects receiving endocrine (e.g., prednisone, other glucocorticoids) or neuroactive (e.g., dilantin, phenobarbital) drugs or any drugs known to influence bone and calcium metabolism
Subjects who smoke cigarettes or vape
Regular consumption of dried plum or prune juice
Parallel
Prune
Dietary supplement30 g of prune/day
Changes from baseline in bone mineral density at 12 and 24 months
bone mineral density as assessed by dual energy x-ray absorptiometry
Changes from baseline in bone specific alkaline phosphatase at 12 months and 24 months
bone specific alkaline phosphatase (BAP) as assessed with ELISA
Changes from baseline in tartrate acid phosphatase-5b at 12 months and 24 months
tartrate acid phosphatase-5b (TRAP5b) as assessed with ELISA
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