Develop an emergency PanorOmics Wide Association Study (ePWAS) for the early, rapid biological and pathophysiological characterisation of known and novel Infectious Diseases in adult patients presenting to emergency departments with suspected, acute, community-acquired respiratory infectious disease (scaRID).
Phase 1
1. Develop an ED-ID biobank (named ePWAS-RID). Phase 2 2. Targeted research for the discovery of novel diagnostics, prognostics and therapeutics
Adults ≥18 years of age; AND
Suspected, acute, community-acquired, respiratory, infectious disease (scaRID)*; AND
Informed consent.
Community acquired (not hospitalised for <28 days); AND
Refusal of consent;
Recent hospitalisation (<28 days);
Enrolled in another clinical trial
Cellulitis;
Suspected, acute, community-acquired, respiratory, infectious disease presenting to emergency department with symptom onset \<8 days and reported fever or chills or aural temperature \>37.5°C
Case-control
Prospective
Biomarker blood draw and saliva collection
Diagnostic testThree peripheral 10 - 20mL blood sample (if available) Three 1 - 5mL salivary samples (if available)
7
Treatment groupsSee each treatment group below.
WHO-CPS
Differentiation of WHO-CPS \>6 from WHO-CPS ≤6
Mortality
Mortality is defined as all-cause, Binary: Yes or No
Mortality
Mortality is defined as all-cause, Binary: Yes or No
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