Emotions From Salivary Biomarkers in an Architectural Context
ConditionEmotions
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorSys2Diag
About this trial
Architecture influences our well-being. People's behavior and mood changes in different spaces are directly related to the architectural qualities of the built environment. Neuroarchitecture is a discipline that combines neuroscience and architecture to design spaces adapted to the psychological and physiological needs of users. Several studies related to neuroarchitecture have been conducted according to different architectural parameters such as style, natural environment, lighting, color, and sunlight pattern. Recent studies show that emotional states can be evaluated by physiological responses. This physiological regulation comes from the action of enzymes and hormones that represent the activity of the autonomic nervous system. Measuring specific biomarkers through non-invasive biological tests in saliva provides physiological data on an individual's emotional state in response to stimuli, particularly visual or tactile.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Subject over 18 years old
Subject agreeing to follow the study procedures
Subject capable of understanding the purpose, nature, and methodology of the study
Subject affiliated with a French social security scheme or beneficiary of such a scheme.
Disqualifiers
Subject not affiliated with a French Social Security scheme or not a beneficiary of such a scheme
Subject deprived of liberty, protected adult, vulnerable person, or minor
Subject with proven or suspected chronic infectious disease that could pose a risk of contamination during sample handling (laboratories not equipped to handle this type of sample)
Subject with a deficiency (vision, anosmia) preventing proper interaction with the architectural work
Trial population
Healthy adult volunteers attending the architectural festival who got exposed and/or got an interaction with an architectural work, with visual, tactile, and/or olfactory stimuli.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Bio-fluid analysis for the measurement of salivary biomarkers linked to emotions
Diagnostic testSaliva of participants will be sampled for analysis of biomarkers of interest (DHEA, oxytocin, cortisol, alpha-amylase, serotonin, and dopamine) using enzymatic dosage methods or ELISA-type methods carried out using commercial kits.
Treatment groups
60 Participants
are divided into 2 treatment groupsGroup A: ARM VT1 intervention
Group B: ARM O1 intervention
Trial outcomes
Primary outcomes
1
Evaluate the variation of salivary biomarkers, which may be linked to emotions (positive or negative), before and after interaction with an architectural work.
Evaluate the variation of salivary biomarkers, which may be linked to emotions (positive or negative), before and after interaction with an architectural work. This exposure includes a combination of visual, tactile, and/or olfactory stimuli.
Time frame
2 yearsSecondary outcomes
1
Identify a salivary molecular biomarker signature linked to an emotional profile following exposure to an architectural site.
Identify, from measurements of alpha-amylase, cortisol, DHEA, oxytocin, serotonin, and dopamine, one or more profile(s) of biomarker concentration variation, which would differentiate the emotions felt following exposure to an architectural site. These combinations of biomarkers could identify an emotion profile linked to a biomarker signature.
Time frame
2 years2
Compare the identified molecular biomarker signatures between the studied architectural sites (different types of visual, tactile, or olfactory stimuli).
Compare the different combinations of biomarker variations identified previously according to the two studied architectural sites. Indeed, since the two sites are architecturally different, the identified signatures could be different depending on the sites.
Time frame
2 years3
Establish correlations between the identified biomarker signatures linked to emotional profiles and sociodemographic and developmental data.
Compare the biomarker signatures measured after stimulation and the sociodemographic and developmental data to establish correlations between the stimuli, the emotions felt, and age, gender, etc.
Time frame
2 years4
Evaluate the homogeneity of the emotional physiological response following exposure to an architectural site.
Analyze the dispersion of the data obtained for each architectural site according to the day, age, gender, etc.
Time frame
2 yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Sys2Diag
Lead sponsor
Centre National de la Recherche Scientifique, France
Collaborator
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: