Endocrine-exocrine Functions and Prognosis After Pancreatectomy

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20-75
SponsorNational Taiwan University Hospital

About this trial

Pancreatic diseases often require surgery or invasive procedures to provide a chance for a cure. However, due to the pancreas's unique anatomical structure, its relative position to adjacent organs, and its dual endocrine and exocrine functions, the complexity of surgery is increased, impacting the patient's postoperative quality of life. Therefore, this project aims to retrospectively collect basic data, preoperative and postoperative blood tests (blood cell counts, biochemistry, tumor markers, glucose-related, lipid-related), and preoperative and postoperative imaging examinations (CT, MRI, Ultrasound, PET scan, Endoscopy, etc.) of patients who underwent pancreatic surgery at our hospital. We aim to compare whether surgical methods, lesion margin clearance rates, and postoperative remnant pancreatic volume affect the patient's endocrine function, exocrine function, quality of life, and disease prognosis. This analysis is intended to understand the indications, surgery-related factors, and prognosis for patients planning to undergo pancreatic surgery, with the expectation of providing more diverse and specific treatment recommendations for patients with pancreatic diseases in the future

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

All patients scheduled for pancreatectomy

Disqualifiers

Age under 20 years or older than 75 years; Pregnancy

Trial population

All patients received pancreatectomy at National Taiwan University Hospital after 2017

Trial design

Design model

Cohort

Time perspective

Retrospective

Treatments tested in this trial

  • pancreatectomy

    Procedure/Surgery

    all procedures demanding pancreatic parenchyma transaction

Treatment groups

3,500 Participants
are divided into 1 treatment group
Group A: pancreatectomy group1 intervention

Trial outcomes

Primary outcomes

1

postoperative pancreatic endocrine-exocrine functions

1. Pancreatic endocrine function will be measured by incidence of appearance of new-onset or aggravated DM after operation. 2. pancreatic exocrine function will be measured by incidence of appearance of steatorrhea which can be alleviated by replacement of digestive enzyme.

Time frame
6 months after pancreatectomy

Secondary outcomes

Other outcomes

Sponsors and contacts

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