The goal of this observational study is to learn about endothelial damage in major spine surgery, expressed as rise in circulating Syndecan-1.
The main questions it aims to answer are:
* What is the extent of endothelial glycocalyx shedding in major spine surgery? * Are there differences in different type of surgical populations? (adolescent idiopathic scoliosis, adult degenerative spine disease, oncologic surgery)
To do so, blood samples will be drawn from participants at the following timepoints:
* basal * after surgery * if transfusion of Fresh Frozen Plasma: before and after transfusion * Post-Operative Day 1-2-4
Undergoing Major Spine Surgery with estimated blood loss> 25% of total blood volume
American Society of Anesthesiology status 1-2-3
Able to comprehend and sign informed consent.
If age <18 years: parent or legal representative able to comprehend and sign informed consent
Surgery outside of laboratory opening hours
Patients undergoing spine surgery for genetic syndromes/neuromuscular scoliosis
This study will take place in patients undergoing major spine surgery. As a secondary analysis, patients will be divided in three major groups: * Adolescent idiopathic * Adult degenerative spine disease * Cancer surgery
Cohort
Prospective
Not listed
Delta Syndecan-1 before -after surgery
Difference between basal Syndecan-1 level and level at the end of surgery
Post-Operative Syndecan-1 curve
Variation of Syndecan-1 levels at post-operative days 1-2-4
Population differences
Difference in baseline and post-operative Syndecan-1 levels in different populations
Thrombomodulin
Variations of Thrombomodulin levels
Plasma effect
Difference in Syndecan-1 levels before and after fresh frozen plasma transfusion
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