Endothelial Dysfunction and Non-cardiac Surgery
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age45+
SponsorUniversity of Chile
About this trial
Endothelial dysfunction is a cardiovascular disease hallmark. After non-cardiac surgery, cardiovascular events correlate with surgical outcomes. Understanding the role of endothelial function in these events is crucial.
This research aims to study endothelial function and its association with cardiovascular events.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Signed informed consent
Patients 45 years or older
Disqualifiers
Refuse to participate in the study
Myocardial injury or acute myocardial infarction less than two weeks ago
Patients who expect less than 2 days of hospitalization
Patients in whom the troponin elevation is attributed to a secondary cause (for example, sepsis, pulmonary thromboembolism, electrical cardioversion, etc.)
Trial population
Patients scheduled for non-cardiac surgery of 45 years old and older.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
FMD - Troponin measurement
Diagnostic testEchographic FMD evaluation. Pre and post-operative troponin measurements.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Major Cardiac Events
Result composed of myocardial infarction, cardiac arrest, and Death
Time frame
7 days after surgery2
Major Cardiac Events
Result composed of myocardial infarction, cardiac arrest, and Death
Time frame
1 month after surgery3
Major Cardiac Events
Result composed of myocardial infarction, cardiac arrest, and Death
Time frame
3 months after surgery4
Major Cardiac Events
Result composed of myocardial infarction, cardiac arrest, and Death
Time frame
6 months after surgerySecondary outcomes
1
Myocardial Injury
Troponin I elevation
Time frame
1 day after surgery2
Myocardial Injury
Troponin I elevation
Time frame
2 days after surgery3
Myocardial Injury
Troponin I elevation
Time frame
3 days after surgery4
Stroke
Stroke incidence after surgery
Time frame
7 days after surgerySponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Chile
Lead sponsor
Agencia Nacional de Investigación y Desarrollo
Collaborator
Source ClinicalTrials.gov