Endothelial Glycocalyx Damage in Brain Death Organ Donors
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity Hospital Hradec Kralove
About this trial
The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program. By the description of the EG status, we can open room for organ optimization before transplantation and improve the organ function after transplantation in marginal donors.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
patients in critical condition declared as brain dead by clinical examination
Disqualifiers
N/A
Trial population
Patients in the intensive care unit with intracranial pathology are predisposed to brain death. In a time of confirmed brain death by clinical examination, the patients will be enrolled. Confirmatory paraclinical study of brain death is not mandatory for enrollment.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Endothelial glycocalyx damage assessment
Diagnostic testDegradation products of endothelial glycocalyx will be assessed in the blood and urine.
Treatment groups
100 Participants
are divided into 1 treatment groupGroup A: Brain dead organ donors1 intervention
Trial outcomes
Primary outcomes
1
Markers of endothelial glycocalyx damage
Levels of syndecan-1 in serum and urine
Time frame
baseline at the time of inclusionSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov