This study evaluates whether a personalized, supervised exercise program can improve fatigue and physical function in patients with myeloproliferative neoplasms (MPN) and chronic myeloid leukemia (CML). Although many patients achieve good disease control with modern therapies, they often experience persistent symptoms such as fatigue that significantly affect daily life.
Participants will take part in a 12-week exercise program that includes aerobic and resistance training, tailored to their individual fitness level and clinical condition. The program consists of two supervised sessions per week, along with additional home-based aerobic activity. Before and after the program, participants will undergo comprehensive assessments, including cardiopulmonary exercise testing, physical function tests, questionnaires on fatigue and quality of life, and blood sample collection.
The study aims to determine whether this type of exercise program is feasible and safe, and whether it can reduce fatigue and improve physical capacity, quality of life, and biological markers related to inflammation and metabolism. Participants will also be followed after the intervention to evaluate whether the benefits are maintained over time.
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Single group
Participants will take part in a 12-week exercise program that includes aerobic and resistance training, tailored to their individual fitness level and clinical condition.
BehavioralThe intervention consists of a 12-week supervised program combining aerobic and resistance training, delivered twice weekly, with additional home-based aerobic activity to achieve recommended weekly exercise volumes. Exercise intensity is individualized based on baseline clinical and cardiopulmonary exercise testing parameters
Feasibility: Adherence to Exercise Program
Percentage of completed supervised exercise sessions relative to the total prescribed sessions over the intervention period.
Feasibility: Retention Rate
Proportion of participants who complete the 12-week intervention and post-intervention assessment.
Safety and Tolerability
Incidence and type of adverse events related to exercise, including musculoskeletal injuries, cardiovascular events, and clinical complications temporally associated with the intervention.
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Carmen Fava
Lead sponsor
University of Turin, Italy
Sponsor institution
Associazione Italiana contro Leucemie, Linfomi e Mieloma
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
