Enhancing Memory in Cognitive Processing Therapy for PTSD

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60+
SponsorVA Office of Research and Development

About this trial

Several psychotherapies for posttraumatic stress disorder (PTSD) have a strong evidence base for their efficacy, but nonresponse rates are high, particularly among older Veterans. Accumulating evidence indicates that memory deficits and poor learning of therapy contents adversely affect psychotherapy treatment response in PTSD. However, limited research has examined methods for increasing learning of therapy contents in psychotherapy for PTSD. The proposed study aims to examine the feasibility of integrating an intervention to increase learning and memory of psychotherapy content into the provision of a widely used psychotherapy, cognitive processing therapy (CPT), for older adults with PTSD. The ultimate goal of this line of research is to develop novel rehabilitation interventions to increase functioning for individuals with PTSD.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Veterans with DSM-5 diagnoses of PTSD via the Clinician Administered PTSD Scale (CAPS-5)

Disqualifiers

daily benzodiazepine use (due to memory impairing effects)

bipolar or psychotic disorders

current suicidal ideation with plan or intent

current moderate or severe substance use disorder not in remission for >1 month

Trial design

Design model

Single group

Treatments tested in this trial

  • Cognitive Processing Therapy

    Behavioral

    CPT as described in the treatment manual

  • Cognitive Processing Therapy (CPT) + Memory Support

    Behavioral

    CPT+Memory support will also incorporate frequent and intentional use of strategies to enhance learning and memory of this content.

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: Cognitive Processing Therapy (CPT)Active comparator 1 intervention
Group B: Cognitive Processing Therapy (CPT) + Memory SupportExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

PTSD Checklist-5 (PCL-5)

Questionnaire for symptoms of PTSD; the range of the scale is from 0 (no symptoms) to 80 (maximal symptoms)

Time frame
Through study completion, weeks 12-16 of treatment

Secondary outcomes

Other outcomes

1

Client Satisfaction Questionnaire (CSQ)

8-item patient satisfaction scale; the range of the scale is from 8 to 32, where low scores are indicative of low satisfaction and high scores are indicative of high satisfaction

Time frame
Through study completion, weeks 12-16 of treatment

Sponsors and contacts

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