Enhancing Renal Graft Function During Donor Anesthesia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorNazmy Edward Seif
About this trial
Renal transplantation is now recognized as the treatment of choice for patients with end-stage renal disease. An optimum anesthetic regimen should enhance the function and perfusion of the transplanted kidney. The aim of this study is to assess \& compare the effectiveness of 3 different modalities in this respect: Mannitol, Dopamine and adequate hydration.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
end-stage renal disease, for living-donor kidney transplantation
Disqualifiers
severe cardiac or hepatic dysfunction
coagulopathy
Trial design
Design model
Parallel
Treatments tested in this trial
Mannitol infusion
Procedure/SurgeryInfusion of Mannitol 20% at a dose of 0.5 mg/kg to the renal graft donor after induction of anesthesia over 15 minutes.
Dopamine infusion
Procedure/SurgeryInfusion of Dopamine at a dose of 4 microg/kg/min to the renal graft donor after induction of anesthesia till ligation of the renal artery.
Adequate hydration
Procedure/SurgeryInfusion of Ringer Acetate at a rate of 15 ml/kg/hr to the renal graft donor after induction of anesthesia till ligation of the renal artery.
Treatment groups
60 Participants
are divided into 3 treatment groupsGroup A: M groupActive comparator 1 intervention
Group B: D groupActive comparator 1 intervention
Group C: C groupActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Post-operative creatinine clearance
Post-operative creatinine clearance level of the transplanted kidney graft is measured in ml/min
Time frame
7 daysSponsors and contacts
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Nazmy Edward Seif
Lead sponsor
Cairo University
Sponsor institution
Source ClinicalTrials.gov