About this trial
Rib fractures happen in about 10-20% of patients with blunt trauma and can be serious, with higher death rates in older adults. These injuries often lead to lung problems like pneumonia, collapsed lung areas (atelectasis), fluid buildup, or even respiratory failure. A major reason for this is pain-patients avoid deep breathing and coughing, which worsens lung function. Good pain control helps prevent these complications.
Opioids are commonly used for pain but can cause problems such as slowed breathing, delirium, nausea, and longer time on a ventilator. Because of this, regional anesthesia (nerve blocks) is increasingly used to control pain while reducing opioid use. Common options include epidurals, paravertebral blocks, and newer techniques like erector spinae plane (ESP) and serratus anterior plane (SAP) blocks. Continuous catheter techniques are especially useful in trauma patients because they can provide ongoing pain relief and have fewer contraindications than epidurals.
The SAP block is done at the side of the chest and works well for rib fractures in the front and side. It may not work as well for fractures in the back, although trauma may sometimes allow the anesthetic to spread further than expected.
The ESP block is done near the spine and may cover a broader area, including both front and back of the chest. It is relatively easy to perform at the bedside and is considered safe. Studies suggest it provides pain relief similar to epidurals in some patients.
There is still limited evidence directly comparing continuous SAP and ESP catheters. Only one study (using single injections) suggests ESP may provide better pain relief. It is unclear whether that difference holds true with continuous infusions, or whether SAP might be preferable because it is easier and quicker to perform.
We propose a randomized trial comparing continuous ESP and SAP catheters in patients with rib fractures to determine which provides better pain control, reduces opioid use, improves breathing outcomes, and is easier to perform in routine practice.
Our hypotheses are that ESP will provide better pain relief, SAP will be easier and safer to place, and both techniques will reduce opioid use while maintaining good patient comfort and breathing.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age >18;
Traumatic rib fractures (unilateral or bilateral);
Minimum of 3 rib fractures per side;
Admitted to hospital for <72 hours
Disqualifiers
Severe traumatic brain injury (Glasgow Coma Scale < 9);
Surgery performed/planned within 72 hours of catheter infusion start;
Uncontrolled coagulopathy;
Skin infection or anatomical abnormality (i.e. open fracture) at insertion sites;
Trial design
Parallel
Treatments tested in this trial
Erector spinae plane catheter
Procedure/SurgeryParticipants receive erector spinae plane catheter infusion
Serratus plane catheter
Procedure/SurgeryParticipants receive serratus plane catheter infusion
Treatment groups
Trial outcomes
Primary outcomes
Pain with movement
Pain Numerical Rating Scale scores with movement from baseline through 72 hours post-placement. Numerical Rating Scale minimum is 0, maximum is 10, higher score = worse pain.
Secondary outcomes
Total opioid consumption
Total opioid consumption (IV and oral) between the SAP and ESP groups at 24, 48, and 72 hours post-catheter placement
Respiratory function
forced expiratory volume in 1 second (FEV1), FEV1% of predicted, forced vital capacity (FVC), and peak inspiratory and expiratory flow will be measured using portable spirometry at baseline, 24 (± 4 hours), 48 (± 6 hours), and 72 (± 6 hours) hours post-catheter placement
Ease of catheter insertion between techniques
Number of skin puncture attempts
Pain at rest
Pain Numerical Rating Scale scores at rest from baseline through 72 hours post-placement. Numerical Rating Scale minimum is 0, maximum is 10, higher score = worse pain.
Other outcomes
Patient satisfaction
Patient satisfaction scores using Patient Global Impression of Change (PGIC)
Catheter-related complications
Catheter-related complications including infection, dislodgement, local anesthetic toxicity, and pneumothorax within the 72 hour study period
Catheter function
Duration of catheter function (days of infusion)
Hospital length of stay
Total hospital length of stay (measured in days)
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options: