Eribulin Mesylate-based Therapy in Patients With Advanced HER2-negative Breast Cancer Previously Treated With ADC

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorFudan University

About this trial

This study is a real-world study. we collected patients with advanced HER2-negative breast cancer previously treated with antibody-drug conjugates, and received eribulin mesylate-based therapy post-ADC. We retrospectively collect the data on previous systemic treatment, and prospectively collect the treatment data of the therapeutic regimens based on eribulin mesylate.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

At least 18 years old;

Inoperable locally advanced or metastatic breast cancer;

Planning to use a single-agent or combination treatment regimen based on eribulin;

HER2 negative (IHC 0,+, or ++ but ISH negative);

Disqualifiers

HER2-positive tumors

The hormone receptor status is unknown;

Patients who have received eribulin treatment before;

Those who have had other malignant tumors within the past 5 years (excluding the following situations: cured skin basal cell carcinoma, cervical carcinoma in situ, papillary thyroid carcinoma; second primary cancer that has been cured and has no recurrence within 5 years; subjects who have clearly identified the origin of the metastatic lesion as being from a certain primary tumor);

Trial population

Advanced HER2-negative breast cancer patients previously treated with ADC

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

400 Participants
are grouped into 1 trial group
Group A: advanced HER2-negative breast cancer patients previously treated with ADC

Trial outcomes

Primary outcomes

1

Progression-Free Survival (PFS)

the period from the start of eribulin mesylate-based therapy treatment until the disease progress or death from any cause, whichever occurred first

Time frame
From enrollment to the last patient experiences disease progression or completes the 24-month follow-up.

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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