Health TrialsbyHealthPanel

Establishing New Treatment Approaches for Amblyopia: Perceptual Learning and Video Games

ConditionAmblyopia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorNova Southeastern University

About this trial

Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

adults and children with normal vision or amblyopia

amblyopia: interocular VA difference of 0.1 logMAR or more

Disqualifiers

any ocular pathological conditions, nystagmus

Trial design

Design model

Crossover

Treatments tested in this trial

  • Video Game Vision Training

    Behavioral

    A new approach for improving amblyopic vision using video games

  • Perceptual Learning

    Behavioral

    A new approach for improving amblyopic vision with perceptual learning

  • Occlusion Therapy

    Behavioral

    Conventional treatment for amblyopia

Treatment groups

180 Participants
are divided into 3 treatment groups
Group A: Video GamesExperimental treatment 1 intervention
Group B: Perceptual learningExperimental treatment 1 intervention
Group C: Occlusion therapyActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Change in visual acuity before and after the intervention

"Visual acuity", the gold standard for vision testing, will be measured. Participants will be asked to read letters on a LogMAR letter chart. The smallest letters that can be read correspond to visual acuity (e.g., Snellen acuity of 20/20, letter-stroke width = 1 minute of arc).

Time frame
9 months
2

Change in stereoacuity before and after the intervention

"Stereoacuity" will be measured psychophysically using a new stereoacuity function test (1.25, 2.5, 5, 10, 15, \& 20 cycles per degree) developed in our previous studies (Li et al 2016). A custom-built 4-mirror haploscope will be used to present a stereogram to each eye. Stereoacuity is the smallest stereo disparity that can be seen in binocular vision (in the unit of seconds of arc, arcsec). The conventional stereoacuity tests (including Randot Stereoacuity Test, Stereofly Test \& Preschool Stereo Test) will also be used to measure stereoacuity. Participants will be asked to wear a pair of 3D glasses and to identify the target 3D pictures at various 3D levels. The smallest 3D disparities that can be seen correspond to stereoacuity (e.g. normal range of stereoacuity: 50 seconds of arc or better).

Time frame
9 months

Secondary outcomes

1

Change in contrast sensitivity before and after the intervention

"Contrast sensitivity", the ability to detect low contrast / brightness, will be measured psychophysically for a range of spatial frequencies (1.25, 2.5, 5, 10, \& 20 cycles per degree). Visual stimuli at different contrast levels will be displayed on a monitor screen. The smallest detectable stimulus contrast level will be measured in the unit of cd/m2.

Time frame
9 months
2

Change in positional (or Vernier) acuity before and after the intervention

"Positional acuity", the ability to detect a subtle positional offset between visual stimuli, will be measured psychophysically. Visual stimuli with different amount of positional offsets will be displayed on a monitor screen. The smallest detectable stimulus offset will be measured as position acuity, in the unit of seconds of arc.

Time frame
9 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Nova Southeastern University

Lead sponsor

Source ClinicalTrials.gov
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