Establishment of a Cohort of Patients With Sepsis-associated Encephalopathy (SAE)
ConditionSepsis-Associated Encephalopathy
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-89
SponsorYi Li, MD
About this trial
In this study, the researcher involved the sepsis patients(defined by sepsis 3.0) in Peking Union Medical College Hospital. The SAE was defined as the Glasgow Coma Scale (GCS) score of less than 15 and the Non-SAE group GCS = 15. The control group was the non-infectious patients with acute disease strikes and the healthy control. After the sample collection, the RNA-sequence, metabolites and cytokines were under detection.
Eligibility criteria
Qualifiers
sepsis 3.0 diagnostic criteria;
Estimated length of hospital stay> 24h;
ages 18-89;
Acute brain dysfunction: delirium, coma, epilepsy, focal neurological deficit;
Disqualifiers
Diagnosis of patients with brain injury before admission, including Alzheimer's disease, craniocerebral injury, etc .;
Primary brain injury (cerebral hemorrhage, cerebral infarction, etc.), secondary brain injury (liver brain, lung brain, uremia encephalopathy, pancreatic encephalopathy, metabolic encephalopathy, Wake encephalopathy, etc.);
pregnant and lactating women;
Those who have undergone bypass surgery in the past 3 months;
Trial design
Treatments tested in this trial
- No intervention
Treatment groups
3,000 Participants
are divided into 3 treatment groupsSponsors and collaborators
Yi Li, MD
Lead sponsor
Peking Union Medical College Hospital
Sponsor institution
Source ClinicalTrials.gov