The goal of this observational study is to better understand cognitive and affective processes involved in depression, in particular how individuals estimate their perception of control over events in their environment, as well as related processes such as memory and decision-making. The study also aims to investigate how these processes are affected by antidepressant treatment and how depressive symptoms evolve over time, as well as whether specific peripheral markers (including hormones) are associated with treatment effects.
Affiliated with a social security or national health insurance system, or entitled to such coverage.
Male or female, aged 18 to 55 years.
Fluent in spoken and written French.
Normal or corrected-to-normal vision.
History of a major depressive episode within the past 3 years.
Use of antidepressants, mood stabilizers, or antipsychotic medication within the past 3 years.
Diagnosis of a neurological or psychiatric disorder affecting central nervous system function (including bipolar disorder, schizophrenia, or other psychotic disorders according to DSM-5 criteria).
Pregnancy or breastfeeding (self-reported).
Parallel
Selective Serotonin Reuptake Inhibitors (SSRIs) or serotonergic antidepressants
DrugParticipants are prescribed serotonergic antidepressants such as fluoxetine, sertraline, escitalopram, paroxetine, or serotonin-norepinephrine reuptake inhibitor (SNRI). Dosage, formulation, frequency, and treatment duration are determined by the treating clinician. No experimental manipulation of medication is performed within the study. The intervention is characterized to assess its association with cognitive performance, reaction time (RT), accuracy, and controllability-related decision-making.
Experimental tasks
Other interventionExperimental tasks assessing cognition, decision-making, and perceived controllability.
Controllability Estimation Bias in depressed patients
normalization of the controllability estimation bias in patients with depression after 8 weeks of treatment with a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI). The assessment of controllability is not obtained directly from the participant, but through a computational model inferred from their behavioural data (reaction time (RT), prediction accuracy (percentage of correct responses) and error rate)
Controllability Estimation Bias in Depressed Patients vs Healthy Controls
This measure compares the controllability estimation bias between participants with a current depressive episode and healthy controls using a behavioral task assessing perceived control over environmental outcomes
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Hôpital le Vinatier
Lead sponsor
INSERM U1028
Collaborator
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