This trial is a prospective multi-center study. The purpose of this study is to evaluate the effect of dietary supplement combined with supervised exercised on the physical performance, body composition and lung function among patients with Sarcopenia and severe Sarcopenia in chronic lung disease. After participants enroll in this study, 12-week clinical trial will be conducted to analyze the improvement regarding Sarcopenia and different severity of Sarcopenia before and after the intervention of exercise and nutritional products, which can further provide reference for clinical intervention and rehabilitation.
Outpatients with COPD (chronic obstructive pulmonary disease) or ILD (interstitial lung disease) from Department of Chest medicine in Taichung Veterans General Hospital, judged by the doctor that they do not need hospitalization or emergent treatment.
Outpatients who meet the diagnostic criteria for Sarcopenia after evaluation by a physician.
Patients who refuse to sign the consent form
Patients who are under 20 years old
Patients who are bedridden or unable to walk due to physical disabilities
Patients with terminal cancer or human-acquired immunodeficiency syndrome
Single group
Sarcojoint®
Dietary supplementAll participants are administered Sarcojoint® containing leucinine 1 g, arginine 1.5 g, Vitamin D 7.5μg, chondroitin 400 mg, calcium 300 mg, and glucosamine 700 mg per package, and take 1 package twice a day.
supervised exercise
BehavioralAll participants are required to walk 6500 steps every day for 12 weeks, and the data are recorded by Xiaomi-smart-band.
Change of physical performance (Grip strength)
Grip strength (kg) Instrument: Smedley dynamometer
Change of physical performance(Sit to stand test) :SpO2%, HR, Borg score, times and second will be reported to present the result of Sit to stand test.
SpO2%, HR, Borg score, times and second
Change of physical performance (SPPB): Sit to stand test, balance test and 4-meter walk test will be combined to report SPPB score
Sit to stand test, balance test and 4-meter walk test will be combined to report SPPB score
Change of physical performance :6-meter walk test (second)
5\. 6-miniute walk test ( SpO2%, HR, Borg score, and the walking distance will be reported to present the result of 6-miniute walk test. )
SARC-Calf questionnaire
compare the effect of the same intervention on Sarcopenia and different severity of Sarcopenia.
Grip strength test
compare the outcome of physical performance of the same intervention on Sarcopenia and different severity of Sarcopenia.
Sit-stand test
compare the outcome of physical performance of the same intervention on Sarcopenia and different severity of Sarcopenia.
Short physical performance battery (SPPB)
compare the outcome of physical performance of the same intervention on Sarcopenia and different severity of Sarcopenia.
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