Evaluating In-line Chlorination in Nigeria

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age15+
SponsorUniversity of California, Berkeley

About this trial

This study evaluates the implementation and effectiveness of in-line chlorination (ILC) for improving drinking water quality in rural Nigeria. Unsafe drinking water remains a major contributor to diarrheal disease, particularly among children under five. Inline chlorination is a passive water treatment approach that automatically doses chlorine at community water systems without requiring electricity or daily user action. Two cluster randomized controlled trials will be conducted in Kano State (North-West Nigeria) and Cross River State (South-South Nigeria). Communities will be randomized to either receive in-line chlorination installed at eligible communal water systems or serve as controls with no chlorination. The unit of randomization is a community or a cluster of communities that share water system for drinking water. The primary objective is to estimate the causal impact of in-line chlorination on household drinking water quality. Outcomes include the prevalence of Escherichia coli contamination in tap water and stored household water as well as the presence of free chlorine residual. Secondary objectives assess water source usage and adoption of chlorinated sources, as well as reduction in diarrheal disease. Implementation fidelity and operational performance of chlorination devices will also be monitored.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adult (18+) or emancipated minor (15+) pregnant women and women with children under 5 years old who do not plan to permanently move in the next 12 months.

Must be knowledgeable about the household's water collection and management practices

Disqualifiers

Non-age-eligible women. Men and non-emancipated minors. Women who do not consent.

Trial design

Design model

Parallel

Treatments tested in this trial

  • In-line Chlorination (ILC) with Behavioral Change Communication (BCC)

    Device

    In-line chlorination devices will be installed on all compatible communal water systems within treatment communities. Devices automatically dose chlorine proportional to water flow without requiring electricity or daily user input. Technologies will include TuriTap liquid dosers installed at handpumps and CTI-8 tablet dosers installed at tanks or piped systems. Devices will be calibrated and routinely monitored to maintain chlorine residual within recommended ranges. In addition to device installation, communities will participate in behavior change communication (BCC) activities designed to support understanding and acceptance of chlorinated water. BCC activities will include community sensitization meetings conducted by the implementing partner. Meetings will provide information on the purpose of chlorination through the in-line chlorination devices, expected benefits and limitations, safe water handling practices, and guidance for addressing taste or odor concerns.

Treatment groups

2,655 Participants
are divided into 2 treatment groups
Group A: Arm 1: Inline Chlorination (ILC) with Behavioral Change Communication (BCC)Experimental treatment 1 intervention
Group B: Arm 2: Control (No Chlorination)No intervention 0 interventions

Trial outcomes

Primary outcomes

1

Proportion of water source samples with detectable free chlorine residual.

Measured as \>0.1 ppm.

Time frame
About 4-, 8-, and 12-month follow ups after device installations
2

Proportion of household stored drinking water samples with detectable free chlorine residual.

Measured as \>0.1 ppm.

Time frame
About 4-, 8-, and 12-month follow ups after device installations
3

Proportion of household stored drinking water samples positive for Escherichia coli.

Measured as \>1 MPN/100 mL of water by culture-based assay

Time frame
About 4-, 8-, and 12-month follow ups after device installations

Secondary outcomes

1

Proportion of water source samples with detectable total chlorine residual.

Measured as \>0.1 ppm.

Time frame
About 4-, 8-, and 12-month follow ups after device installations
2

Concentration of E. coli in water source samples

Concentration of E. coli (in log10 MPN/100ml) in water source samples by culture-based assay

Time frame
About 4-, 8-, and 12-month follow ups after device installations
3

Concentration of E. coli in household stored water samples

Concentration of E. coli (in log10 MPN/100ml) in household stored water samples by culture-based assay

Time frame
About 4-, 8-, and 12-month follow ups after device installations
4

Concentration of total coliform bacteria in water source samples

Concentration of total coliform bacteria (MPN/100mL) in water source samples

Time frame
About 4-, 8-, and 12-month follow ups after device installations

Other outcomes

1

Proportion of households reporting an ILC-compatible water source as their primary drinking water source

Measured as the percentage of surveyed households identifying an ILC-compatible water system as their source of drinking water. ILC-compatible water systems (boreholes, piped systems, or handpumps have chlorinated water in treatment)

Time frame
About 4-, 8-, and 12-month follow ups after device installations
2

Proportion of households switching away from ILC-treated water sources

Measured as the percentage of households that discontinue use of a chlorinated water system for drinking water compared to baseline.

Time frame
About 4-, 8-, and 12-month follow ups after device installations
3

Proportion of households reporting any household-level water treatment

Measured as the percentage of households reporting treatment of drinking water prior to consumption (e.g., boiling, filtration, manual chlorination).

Time frame
About 4-, 8-, and 12-month follow ups after device installations
4

Time spent on household-level water treatment

Time (minutes) reported by households per day on making water safer to drink (gender stratified)

Time frame
About 4-, 8-, and 12-month follow ups after device installations

Sponsors and contacts

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University of California, Berkeley

Lead sponsor

University of Michigan

Collaborator

Bayero University Kano, Nigeria

Collaborator

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