The effect of internal mammary irradiation (IMI) added to whole-breast or thoracic-wall irradiation plus supraclavicular (SVC) irradiation after surgery on survival among women with early-stage intermediate risk (N1) breast cancer remains debated. The present study aimed to identified patient could be omitted from internal mammary lymph node irradiation by using a clinical-genomic model.
• Histologically confirmed invasive breast cancer
Underwent radical surgery with either mastectomy or breast conserving surgery and axillary lymph node dissection (ALND)
The number of positive lymph node should be 1-3 (N1).
Clinical high risk breast cancer (≥2 clinical risk factors)
• Axillary dissection of less than 10 lymph nodes
Pathologically positive ipsilateral supraclavicular lymph node
Pathologically or radiologically confirmed involvement of ipsilateral internal mammary lymph nodes
Pregnant or lactating women