The goal of this clinical trial is to learn whether high-dose multimodal prehabilitation, delivered either in person or remotely with coaching and web application support, is feasible and acceptable for women preparing for ovarian cancer surgery. It will also examine which delivery model patients prefer and the factors influencing patient preferences.
The main questions ADAPT-OC aims to answer are:
1. Can participants achieve the prescribed aerobic exercise target of at least 10 MET-hours per week before surgery? 2. Do patients prefer in-person prehabilitation, remote prehabilitation, or education-only care, and what factors influence that preference?
The researchers will compare in-person prehabilitation, remote prehabilitation, and education-only care to see which delivery approach is most feasible, acceptable, and practical for patients with suspected ovarian cancer.
Participants will:
* Choose their preferred study group, or be randomly assigned if they have no preference * Complete physical assessments, questionnaires, and interviews at baseline, 1-3 days before surgery, and 4 weeks after surgery * If assigned to a prehabilitation group, complete aerobic exercise, protein supplementation, and daily breathing exercises before surgery * Attend weekly coaching sessions with a trained prehabilitation coach * Use the KingstonPrehab web application to track exercise, nutrition, breathing practice, and progress toward activity goals
Female
Aged ≥18 years
Scheduled for cytoreductive surgery for an ovarian mass suspected or confirmed of cancer
Surgery planned ≥3 weeks from time of booking
Pregnancy
Surgery scheduled <3 weeks from booking
Receiving neoadjuvant chemotherapy
Positive contraindications to exercise on the CSEP Get Active Questionnaire
Parallel
Multimodal Prehabilitation Program
BehavioralThe multimodal prehabilitation program consists of progressive aerobic exercise targeting at least 10 MET-hours/week above baseline via 3-5 sessions per week, daily protein supplementation (BOOST Carb Smart; Nestlé Canada Inc.; North York, Ontario, Canada), daily box breathing for stress management, weekly one-on-one behavioural coaching sessions with a trained prehabilitation coach, and use of the KingstonPrehab web application for self-monitoring and progress tracking. Aerobic exercise sessions will be supervised on site. This intervention is delivered either in-person or remotely depending on study arm allocation.
Educational Materials
Other interventionParticipants receive standardized educational materials describing the principles of prehabilitation, including aerobic exercise, resistance exercise, nutrition focusing on perioperative protein intake, and stress management strategies. Participants will also receive a postoperative recovery handbook adapted from the Montreal General Hospital Prehabilitation Clinic that provides guidance on nutrition, pain and constipation management, mobilization, in-hospital exercise, and a progressive return-to-activity plan for the first 8 weeks after surgery.
Behavioural adherence to exercise target (≥10 MET-hours/week)
Individual aerobic exercise adherence, expressed as a percentage of the minimum prescribed target (≥10 MET-hours/week above baseline), capped at 100%. (Go ≥75%, Amend 61-74%, Stop \<60%)
Patient preference for delivery model
Proportion selecting in-person, remote, or education-only arms. Qualitative exploration of reasons for preference.
Recruitment rate
Proportion of eligible patients approached who consent and enroll.
Retention rate
Proportion of enrolled participants completing all study assessments through 4-week postoperative follow-up.
Intervention adherence
Separate adherence to aerobic exercise, protein supplementation, breathing practice, and coaching attendance. Expressed as a percentage of completed / prescribed. Summarized individually per component, and as composite score.
Adverse events
Any medical events potentially related to exercise, nutrition, or behavioural intervention components.
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Jordan Leitch
Lead sponsor
Queen's University
Sponsor institution
Kingston Health Sciences Centre
Collaborator
Queen's University
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
