Evaluating Treatments for Suicidal Veterans With PTSD

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorVA Office of Research and Development

About this trial

Posttraumatic Stress Disorder (PTSD) is a significant driver of suicide risk among Veterans, but there is a critical knowledge gap about how to treat PTSD among people at elevated risk for suicide. Although evidence-based treatments for PTSD reduce suicide risk, Veterans at high risk for suicidal behavior rarely receive these potentially life-saving treatments. Prior research suggests that a treatment that combines Dialectical Behavior Therapy (DBT) with the DBT Prolonged Exposure protocol (DBT PE) for PTSD improves both PTSD and suicide-related outcomes. This study will evaluate whether DBT + DBT PE improves these outcomes more than Prolonged Exposure plus suicide risk management, the gold standard VA care for this population. The proposed study will also examine factors that make it easier and harder to implement these treatments in VA settings. The results will help to inform treatment guidelines for this high-priority Veteran population.

Eligibility criteria

Qualifiers

PTSD

Recent and repeated self-directed violence

Current suicidal ideation

Emotion dysregulation

Disqualifiers

Unable to maintain safety independently

Currently engaged in and/or recent (past year) history of receiving a sufficient dose of DBT or PE

Plan to move away or be unavailable for >4 weeks in the next 18 months

Unable to sufficiently comprehend study procedures due to lack of English proficiency or moderate to severe cognitive impairment

Trial design

Treatments tested in this trial

  • Dialectical Behavior Therapy
  • Dialectical Behavior Therapy Prolonged Exposure protocol
  • Prolonged Exposure therapy
  • Suicide risk management

Treatment groups

125 Participants
are divided into 2 treatment groups