This is a randomized, double-blind, placebo-controlled pilot study designed to evaluate the effect of an oral nutritional supplement containing Melissa officinalis formulated in phospholipids on mood and cortisol levels in healthy adults. Participants will be randomly assigned to receive either the active supplement or a placebo daily for 3 weeks. The primary outcome measures include changes in mood well-being, perceived stress, and salivary cortisol levels. The study aims to assess both efficacy and safety of the supplement in modulating stress response and emotional balance.
Age between 18 and 65 years
Healthy volunteers as assessed by medical history and physical examination
Willingness to comply with the study procedures
Current use of medications or supplements that may affect mood or cortisol levels
Known allergy or sensitivity to Melissa officinalis or phospholipids
History of psychiatric disorders (e.g., major depression, anxiety disorders)
Significant comorbidities (e.g., cardiovascular, hepatic, renal diseases)
Single group
Melissa officinalis supplement
Dietary supplementThis intervention consists of a standardized oral dietary supplement containing 400 mg of Melissa officinalis extract formulated in phospholipids. The supplement is administered once daily for 3 weeks to evaluate its potential effects on mood, stress perception, and cortisol levels in healthy adults.
Change in perceived stress levels measured by the Perceived Stress Scale (PSS)
The PSS is a validated 10-item questionnaire that assesses the perception of stress over the past month. Scores range from 0 to 40, with higher scores indicating greater stress. The change from baseline to 3 weeks will be measured.
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