Health TrialsbyHealthPanel

Evaluation of a Vaccine Chatbot on HPV Vaccine Confidence and Hesitancy

ConditionHPV Vaccine
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age15-45
SponsorFudan University

About this trial

The goal of this clinical trial is to learn if a chatbot powered by artificial intelligence works to improve HPV vaccination among females aged 15 to 45 in China. A randomized controlled trial and implementation science study will be conducted targeting females as participants. The main questions it aims to answer are:

1. Does the vaccine chatbot influence women's confidence, literacy, hesitancy, and uptake of the HPV vaccine. 2. What are the public acceptance of chatbot and the facilitators and barriers to its implementation in a real-world setting.

Researchers will compare a group of women who use the chatbot with a group who do not use it to see if the chatbot is effective at helping women feel confident and willing to get vaccinated against HPV.

Participants will:

1. Be recruited and randomly allocated into one of two groups. One group will be invited to use the HPV vaccine chatbot and the other group will not get access to the vaccine chatbot until the end of the trial. 2. Complete a questionnaire survey on their confidence, literacy, and hesitancy on the HPV vaccine. 3. Have their vaccination status checked at the end of trial.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Female, aged 15 to 45 years, inclusive.

Not previously vaccinated against HPV.

Reports no contraindications to HPV vaccination.

Has no mental, visual, or reading impairments that would preclude cooperation with study activities.

Disqualifiers

Male.

Age under 15 or over 45 years.

Has a history of prior HPV vaccination.

Has a known contraindication to HPV vaccination.

Trial design

Design model

Parallel

Treatments tested in this trial

  • LLM-Powered HPV Vaccine Chatbot

    Behavioral

    A vaccine chatbot delivered via WeChat or a web browser, designed to provide information and health education about the HPV vaccine. The chatbot is powered by large language models and is trained on an expert-validated knowledge base derived from authoritative sources such as the WHO and China CDC to ensure accuracy. The knowledge base is validated by experts. The chatbot engages users in interactive, conversational dialogue to answer questions and address concerns regarding HPV and HPV vaccines.

Treatment groups

1,800 Participants
are divided into 2 treatment groups
Group A: Chatbot Intervention GroupExperimental treatment 1 intervention
Group B: Control GroupNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

HPV Vaccine Uptake

Whether participants get vaccinated against HPV, measured by official vaccination records.

Time frame
Three months after participant randomization allocation

Secondary outcomes

1

HPV Vaccine Hesitancy

HPV vaccine hesitancy will be measured to assess a participant's plan to receive the HPV vaccine within one year, with five response options ranging from "definitely yes" to "definitely no". It will be categorized as hesitant or not.

Time frame
The same day after the intervention
2

HPV Vaccine Confidence

Vaccine Confidence Index (VCI) that assesses confidence in the importance, effectiveness, and safety of vaccines using a 5-point Likert scale (1 = strongly disagree, 5 = strongly agree). A higher score indicates greater confidence.

Time frame
The same day after the intervention
3

HPV Vaccine Literacy

A series of questions about HPV vaccine knowledge and misinformation. Total literacy score is calculated based on the number of 11 questions answered correctly by the participants.

Time frame
The same day after the intervention
4

Timing of HPV Vaccination

Number of days from randomization to receipt of the first HPV vaccine dose, measured by official vaccination records

Time frame
Within three months after participant randomization allocation

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Fudan University

Lead sponsor

Merck Sharp & Dohme LLC

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: