Evaluation of Brain MRI Changes in Cerebral Palsy Patients
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorColumbia University
About this trial
Cerebral palsy (CP) is a neurodevelopmental syndrome characterized by sensorimotor impairment that arises during early childhood defined as a static insult to the developing brain. A key part of the definition for CP is a non-progressive brain injury; however, as individuals with CP age, a functional decline greater than neurotypical individuals is often present. The investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time.
This will be a single-center study that will compare retrospective clinical and imaging data with similar prospective data. The objective is to find out if people with Cerebral Palsy (CP) experience changes in the structures of their brain over time. A key part of the CP definition is that it is a non-progressive brain injury. However, as people with CP age, their function often deteriorates. This study seeks to determine whether changes in the brain structure may result in function changes, as they do in other types of brain injuries.
The investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States, as well as locally. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Have multiple MRI scans of brain and/or spinal cord spaced at least 24 months apart
Between 18-80 years of age with at least one MRI scan after the age of 18
No known central or peripheral neurological disease or injury other than cerebral palsy causing brain degeneration
Inclusion in CPRN registry
Disqualifiers
History of more than one seizure in lifetime
History of known degenerative genetic disorder
History of brain tumor, abscess, or multiple sclerosis
History of moderate or severe head trauma
Trial population
People with cerebral palsy across the United States
Trial design
Design model
Cohort
Time perspective
Other
Treatments tested in this trial
Not listed
Trial groups
30 Participants
are grouped into 2 trial groupsGroup A: Retrospective
Group B: Prospective
Trial outcomes
Primary outcomes
1
Total brain volume
This is a number, measured in cubic millimeters, that includes the output from segmentation of each individual MRI scan per subject.
Time frame
From first MRI scan to second MRI scan, composed of a timespan of at least 2 or more yearsSecondary outcomes
1
Cortical thickness
This is a number, measured in millimeters, that includes the output from segmentation of each individual MRI scan per subject. This is calculated as the shortest distance between gray/white matter boundary and the pial surface in both directions, with an average to produce the final thickness value.
Time frame
From first MRI scan to second MRI scan, composed of a timespan of at least 2 or more years.Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov