Evaluation of Changes in Sleep Efficiency Among PIC DU MIDI Staff Between Nights Spent at Home and Nights Spent in the Workplace Under High Altitude Conditions

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity Hospital, Toulouse

About this trial

Sleep organization and cardiorespiratory parameters are disrupted in extreme conditions such as high altitude. The pathophysiology of medical problems related to acute high-altitude exposure is partially understood, but sleep quality indicators are very rarely measured under these conditions. This lack of information is even more pronounced among employees subjected to cyclical exposure to high-altitude hypoxic stress, as is the case for the employees at the Pic du Midi. These 32 employees regularly report to their occupational physician difficulties in managing their sleep disorders, struggling to distinguish symptoms from objective changes in their sleep cycles. Among them, 13 are on call at the summit of the Pic du Midi (2,877 m), while 19 work there during the day and return home to a lower altitude at night to sleep. The investigators also wish to measure structural changes in sleep and its cardiorespiratory parameters using polysomnography in these 13 employees, comparing nights spent at home at normal altitude with those spent at the summit of the Pic du Midi. These changes will also be compared to those of a group of 19 employees who do not sleep at high altitude..

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Employed at the Pic du Midi for at least one month

Working nights at high altitude (at the Pic du Midi, altitude of 2877m) as part of their professional activity

Person affiliated with or covered by a social security scheme

Free, informed, and written consent signed by the participant and the investigator

Disqualifiers

History of cardiovascular disease

Use of cardiovascular/psychotropic medication

Participant under legal guardianship or other protective regime (guardianship, curatorship)

Pregnant or breastfeeding woman

Trial design

Design model

Parallel

Treatments tested in this trial

  • Sleep recording

    Other intervention

    Polysomnography and questionnaires.

Treatment groups

32 Participants
are divided into 2 treatment groups
Group A: group with overnight on-call duty at high altitude at the Pic du MidiExperimental treatment 1 intervention
Group B: group without night duty at high altitudeActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Comparison of sleep efficiency (total sleep time / total sleep period) under high altitude conditions (at 2877 m) versus without increased altitude (at home)

Sleep efficiency will be compared, according to the ratio = total sleep time (TST)/ total sleep period (PTS) calculated from a polysomnographic recording, between the night spent at high altitude (2877m, at PIC du MIDI) and the second night spent at home (not increased altitude) among PIC du MIDI employees performing on-call nights at high altitude.

Time frame
1 week after the inclusion

Secondary outcomes

1

Comparison of sleep parameters in high altitude conditions versus without increased altitude for the group "with on-call night at high altitude at Pic du Midi"

Sleep parameters (determined according to the criteria of the American Academy of Sleep Medicine (AASM)) measured from a polysomnographic recording will be compared in high altitude conditions versus without increased altitude.

Time frame
1 week after the inclusion
2

Measurement of sleep parameters in low altitude conditions for the group "without on-call nights at high altitude"

Sleep parameters (determined according to the criteria of the American Academy of Sleep Medicine (AASM)) will be measured from a polysomnographic recording under conditions without altitude gain.

Time frame
1 week after the inclusion
3

Evaluation of the relationship between sleep quantification criteria and sleep disorder criteria

Comparison of questionnaire responses and polysomnographic recording

Time frame
1 week after the inclusion
4

Correlation between cardiac parameters and sleep efficiency.

Correlation between heart rate variability and sleep efficiency using polysomnography recording

Time frame
1 week after the inclusion

Other outcomes

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