Health TrialsbyHealthPanel

Evaluation of Chronic Liver Disease Condition and Transplant Prognosis Assisted by Eye Biological Parameters

ConditionsDiagnostic Techniques, OphthalmologicalLiver TransplantationLiver Cirrhoses
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorZhongshan Ophthalmic Center, Sun Yat-sen University

About this trial

This study investigates the correlation between ocular biological characteristics and overall conditions before and after liver transplantation by collecting ocular biological characteristics. Explore whether it is possible to construct a clinical prediction model for liver transplantation by incorporating ocular biometric features, in order to optimize disease management before and after liver transplantation.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age greater than or equal to 18 years old;

Late stage liver disease patients waiting for liver transplantation treatment, as well as patients with varying degrees of cirrhosis;

Can collect complete basic demographic information, liver function blood test indicators, liver pathology and imaging examination results;

Can cooperate with eye OCT, OCTA and other examinations, and obtain qualified examination parameters;

Disqualifiers

History of other organ transplant surgeries;

History of intraocular laser treatment, medication injection, and surgery;

History of high myopia, glaucoma, and retinal choroidal related eye diseases;

History of major systemic diseases other than liver disease;

Trial population

The liver transplant population was recruited from individuals who went to cooperative medical unit for liver transplant registration, while normal individuals were recruited from the project responsible unit.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Ophthalmic examination

    Diagnostic test

    Various ophthalmic examination modalities, including slit lamp photography, fundus photography, optical coherence tomography imaging and optical coherence tomography angiography, etc.

  • General Condition Examination

    Diagnostic test

    Various general condition examination, including blood pressure measurement, blood glucose testing, blood routine examination, coagulation function test, liver function test, etc.

Treatment groups

500 Participants
are divided into 3 treatment groups
Group A: preoperative group2 interventions
Group B: Simple postoperative group2 interventions
Group C: Healthy control group2 interventions

Trial outcomes

Primary outcomes

1

The performance of predicting the prognosis of liver transplantation

Based on the outcomes of early graft dysfunction and 1-year graft survival rate, the area under the receiver operating characteristic curve, specificity, and sensitivity of the model

Time frame
1 week and 1 year after liver transplantation

Secondary outcomes

1

The performance of the model in assessing the severity of liver disease

The confusion matrix of the model based on the MELD score results

Time frame
1 year

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Zhongshan Ophthalmic Center, Sun Yat-sen University

Lead sponsor

First Affiliated Hospital, Sun Yat-Sen University

Collaborator

Second Affiliated Hospital, Sun Yat-Sen University

Collaborator

Guangdong Provincial People's Hospital

Collaborator

Nanfang Hospital, Southern Medical University

Collaborator

Zhongshan People's Hospital, Guangdong, China

Collaborator

Guangdong Provincial People's Hospital, China

Collaborator

First People's Hospital of Foshan

Collaborator

Source ClinicalTrials.gov
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