Health TrialsbyHealthPanel

Evaluation of Emotion-related Salivary Molecular Biomarkers

ConditionEmotion
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-60
SponsorSys2Diag

About this trial

Recent studies show that emotional states can be discriminated by physiological responses. This physiological regulation results from the action of enzymes and hormones that represent the activity of the autonomic nervous system. The measurement of specific biomarkers, using non-invasive biological tests in saliva, would therefore provide physiological data on an individual's emotional state in response to stimuli, particularly olfactory stimuli.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Subject willing to follow study procedures

Subject able to understand the purpose, nature and methodology of the study

Subject has signed informed consent form

Subjects between 18 and 60 years of age.

Disqualifiers

Subjects deprived of liberty, protected adults, vulnerable persons or minors

Subjects with a proven or suspected chronic infectious disease that could entail a risk of contamination during sample handling (laboratories not equipped to handle this type of sample)

Rejection to sign the consent form.

Pregnant or breastfeeding women

Trial population

The population for this study will consist of healthy volunteers who meet the eligibility criteria.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Identication and measurement of a molecular biomarkers signature

    Other intervention

    Levels of the biomarkers of interest (DHEA, pg/mL; Oxytocin, pg/mL; Cortisol, pg/mL; Alpha Amylase, U/mL) will be measured in the saliva of participating subjects by enzymatic assay methods or ELISA-type methods performed using commercial kits.

Treatment groups

240 Participants
are divided into 2 treatment groups
Group A: Bras S Fragrance then placebo1 intervention
Group B: Bras P Placebo then fragrance1 intervention

Trial outcomes

Primary outcomes

1

Evaluate variations

Evaluate variations in several molecular biomarkers in saliva following fragrance stimulus/stimuli that may be linked to an emotionnal response (positive or negative).

Time frame
1 year

Secondary outcomes

1

Identify a molecular biomarker signature

Identify a molecular biomarker signature in saliva following fragrance stimulus or stimuli.

Time frame
2 years
2

Evaluate basal values of biomarkers

Evaluate basal values of biomarkers composing the signature under normal, unstimulated conditions (intra-individual, inter-individual variations, circadian rhythm, age, gender...).

Time frame
3 years
3

Evaluate signature dynamics

Evaluate signature dynamics after stimulation

Time frame
1 year
4

Establish correlations between biomarker signatures and emotion ratings

Establish correlations between biomarker signatures and emotion ratings based on other criteria, such as questionnaires.

Time frame
3 years

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sys2Diag

Lead sponsor

Centre National de la Recherche Scientifique, France

Collaborator

Source ClinicalTrials.gov
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