Caratterizzazione della composizione microbica intestinale nei donatori di FMT e nei pazienti affetti da rCDI al tempo basale e a seguito del trapianto di microbiota fecale. Negli stessi time point valutare il resistoma associato alla comunità microbica rilevata.
patients with rCDI (> 18 years) to whom faecal microbiota transplantation is indicated, without other pathologies or prolonged hospitalization periods
donors: healthy volunteers aged between 18 and 50 years
Patients capable of expressing consent
antibiotic therapies in the last 30 days
treatments with prebiotics - probiotics - postbiotics in the last 60 days
colonization by MDR or XDR pathogens
presence of pre-existing or ongoing intestinal pathologies (Inflammatory Intestinal Diseases, chronic hepatitis, celiac disease, neoplasms, previous large intestinal resections)
CDI patients - FMT donors
Cohort
Prospective
Not listed
Assessment of gut microbiota e associated resitome
Characterization of intestinal microbial composition in FMT donors and patients with rCDI at baseline time and following fecal microbiota transplantation. In the same time points evaluate the resistance associated with the microbial community detected.
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