Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorKanuni Sultan Suleyman Training and Research Hospital
About this trial
The goal of this prospective observational study is to evaluate whether left ventricular function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success from mechanical ventilation in adult intensive care unit (ICU) patients. The main questions it aims to answer are:
Can the Left Ventricular Outflow Tract Velocity Time Integral (LVOT VTI) predict successful extubation?
What is the prognostic value of other echocardiographic measures such as Mitral Annular Plane Systolic Excursion (MAPSE), E/e' ratio, E/A ratio, Mitral Deceleration Time (MDT), and Myocardial Performance Index (Tei index) in forecasting weaning outcomes?
Participants will:
Be adults receiving mechanical ventilation and scheduled for weaning
Undergo transthoracic echocardiography (TTE) within 2 hours after meeting weaning criteria
Have the following parameters measured: LVOT VTI, MAPSE, E/e', E/A, MDT, and Tei index
Be monitored for 24 hours post-extubation to determine if they remain off ventilatory support, including reintubation, non-invasive ventilation, or high-flow oxygen therapy
This study aims to provide a comprehensive understanding of how systolic, diastolic, and global cardiac functions influence extubation success, potentially improving ICU decision-making and reducing complications, length of stay, and healthcare costs.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Currently receiving mechanical ventilation in the ICU
Planned extubation after meeting standard weaning criteria
Hemodynamically stable at the time of echocardiographic evaluation
Written informed consent obtained from the patient or legally authorized representative
Disqualifiers
Surgery within the previous 24 hours
Presence of significant valvular heart disease or known cardiomyopathy
Inadequate acoustic window for transthoracic echocardiography
Ongoing use of extracorporeal support (e.g., ECMO)
Trial population
The study population will consist of adult patients admitted to the intensive care unit (ICU) who are receiving invasive mechanical ventilation and are scheduled for extubation after fulfilling standard weaning criteria. All participants will be hemodynamically stable at the time of echocardiographic assessment. Patients with significant structural heart disease, inadequate echocardiographic imaging windows, or ongoing extracorporeal support will be excluded. The population represents a typical critically ill cohort undergoing weaning from mechanical ventilation.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Echocardiographic Assessment
Diagnostic testAll participants will receive a standardized transthoracic echocardiographic (TTE) examination within 2 hours after meeting weaning criteria. The following cardiac function parameters will be recorded: LVOT Velocity Time Integral (VTI) Mitral Annular Plane Systolic Excursion (MAPSE) E/e' ratio E/A ratio Mitral Deceleration Time (MDT) Myocardial Performance Index (Tei index) The echocardiographic data will be used to investigate the association between left ventricular function and weaning success.
Treatment groups
50 Participants
are divided into 1 treatment groupGroup A: Weaning Candidates1 intervention
Trial outcomes
Primary outcomes
1
Predictive Value of LVOT VTI in Determining Weaning Success
To evaluate whether the Left Ventricular Outflow Tract Velocity Time Integral (LVOT VTI) measured by transthoracic echocardiography (TTE) within 2 hours after fulfilling weaning criteria can predict successful weaning from mechanical ventilation. Successful weaning is defined as maintaining spontaneous breathing for at least 24 hours without requiring reintubation, non-invasive ventilation, or high-flow nasal oxygen therapy.
Time frame
Within 24 hours after extubationSecondary outcomes
1
Predictive Value of Additional Left Ventricular Function Parameters in Weaning Success
To assess whether echocardiographic parameters other than LVOT VTI - including Mitral Annular Plane Systolic Excursion (MAPSE), E/e' ratio, E/A ratio, Mitral Deceleration Time (MDT), and Myocardial Performance Index (Tei index) - are associated with successful weaning from mechanical ventilation. These parameters reflect systolic, diastolic, and global left ventricular function and will be measured using transthoracic echocardiography prior to extubation.
Time frame
Within 24 hours after extubationSponsors and contacts
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Source ClinicalTrials.gov