Health TrialsbyHealthPanel

Evaluation of Neuromuscular Blockade Responses in Statin-Using and Non-Using Patients

ConditionsNeuromuscular BlockadeStatin-Associated MyopathyNeuromuscular Monitoring
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorAnkara City Hospital Bilkent

About this trial

This study aims to compare the neuromuscular blockade responses in patients undergoing elective surgery under general anesthesia, with a focus on the use of statins. The study will assess the depth of neuromuscular blockade, recovery time, and postoperative residual curarization using Train-of-Four (TOF) monitoring, with the primary goal of determining whether statin use alters the neuromuscular blockade management.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 18-75 years

ASA classification I, II, III

BMI 18-30

Statin use for at least 3 months or no prior statin use

Disqualifiers

ASA classification IV or higher

BMI <18 or >30

History of liver or renal insufficiency (creatinine >1.6, liver function tests >2x normal)

Neuromuscular, psychiatric, or neurological disorders

Trial population

Statin-Using and Non-Using Patients Undergoing Elective Surgery Under General Anesthesia

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • TOF (Train-of-Four) monitoring for depth of neuromuscular blockade.

    Diagnostic test

    General anesthesia with propofol and fentanyl induction followed by rocuronium for neuromuscular blockade; maintenance with desflurane and remifentanil.

Treatment groups

104 Participants
are divided into 2 treatment groups
Group A: cohort A: statin-use1 intervention
Group B: Cohort B: statin-nonuse1 intervention

Trial outcomes

Primary outcomes

1

Time to reach TOF count 0

time from administration of rocuronium to reach TOF count 0

Time frame
0th minute
2

Time to reach TOF 40

time to intraoperatively TOF reached 40

Time frame
about 40th minute
3

Time to reach TOF 90 (reversal of neuromuscular blockade)

Measured postoperatively after sugammadex administration and additional doses if required.

Time frame
about 60th minute

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ankara City Hospital Bilkent

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: