Evaluation of Right Ventricular Function to Predict Weaning Success in the Intensive Care Unit
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorKanuni Sultan Suleyman Training and Research Hospital
About this trial
The goal of this prospective observational study is to evaluate whether right ventricular (RV) function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success in adult intensive care unit (ICU) patients who are mechanically ventilated. The main questions it aims to answer are:
Can the TAPSE (Tricuspid Annular Plane Systolic Excursion) value predict successful extubation?
Do other right heart parameters (tricuspid S', RV-FAC, right atrial area, pulmonary valve acceleration time) provide additional prognostic value for weaning outcomes?
Participants will:
Be adult ICU patients planned for weaning from mechanical ventilation.
Undergo transthoracic echocardiography within 2 hours after meeting clinical weaning criteria.
Have the following echocardiographic parameters measured: TAPSE, tricuspid S', RV-FAC, right atrial area, and pulmonary valve acceleration time.
Be monitored for 24 hours after extubation to assess weaning success (defined as no need for reintubation, non-invasive ventilation, or high-flow oxygen support).
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Receiving invasive mechanical ventilation in the ICU
Planned extubation (weaning) according to standard clinical criteria
Hemodynamically stable at the time of transthoracic echocardiography (TTE)
Ability to undergo echocardiographic assessment within 2 hours prior to extubation
Disqualifiers
Known severe tricuspid valve disease or congenital heart disease
Moderate to severe pericardial effusion or cardiac tamponade
Inadequate acoustic window for transthoracic echocardiography
Patients requiring urgent or unplanned extubation
Trial population
Adult patients who are receiving invasive mechanical ventilation in the intensive care unit (ICU) and are scheduled for planned extubation based on standard clinical weaning criteria. All participants must be hemodynamically stable and able to undergo transthoracic echocardiographic assessment prior to extubation.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Transthoracic Echocardiography (TTE)
Diagnostic testNon-invasive ultrasound imaging of the heart to evaluate right ventricular and right atrial function using parameters such as TAPSE, tricuspid S', RV-FAC, right atrial area, and pulmonary valve acceleration time. TTE will be performed once within 2 hours prior to extubation decision as part of routine care.
Treatment groups
60 Participants
are divided into 1 treatment groupGroup A: Mechanically Ventilated ICU Patients Undergoing Weaning1 intervention
Trial outcomes
Primary outcomes
1
Discriminative Ability of TAPSE for Predicting Weaning Success
Assessment of the predictive accuracy of TAPSE (Tricuspid Annular Plane Systolic Excursion) in identifying weaning success, defined as no requirement for reintubation, non-invasive ventilation, or high-flow oxygen within 24 hours post-extubation.
Time frame
Within 24 hours after extubationSecondary outcomes
1
Discriminative Ability of RV-FAC in Predicting Weaning Success
To determine the discriminative performance of right ventricular fractional area change (RV-FAC), measured by transthoracic echocardiography, in identifying weaning success.
Time frame
Within 24 hours after extubation2
Discriminative Ability of Tricuspid S' Velocity in Predicting Weaning Success
To evaluate the ability of tricuspid annular systolic velocity (S'), obtained via tissue Doppler imaging, to discriminate between successful and unsuccessful weaning outcomes.
Time frame
Within 24 hours after extubation3
Correlation of Right Atrial Area With Weaning Outcome
To assess whether right atrial area measured before extubation is associated with weaning success or failure.
Time frame
Within 24 hours after extubation4
Correlation of Pulmonary Valve Acceleration Time with Predicting Weaning Success
To investigate whether pulmonary valve acceleration time (PVAT), measured via transthoracic echocardiography, is associated with weaning success.
Time frame
Within 24 hours after extubationSponsors and contacts
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Source ClinicalTrials.gov