The study aims to evaluate the expression of certain proteins and their diagnostic and prognostic value in precancerous lesions of the cervix.
Patients with a diagnosis of CIN/SIL undergoing cervical biopsy/concussion whose tissue sample is archived at the Operative Unit of Pathological Anatomy and Histology
Obtaining written informed consent for the use of biological samples
Patients aged 18 years and over
None
Single group
Tissue, diagnostic and prognostic accuracy
Diagnostic testThe clinical data and histological samples of patients with a diagnosis of CIN/SIL on cervical biopsies or conization (performed as required by the normal procedure) will be consecutively acquired from all those taken at the Operative Unit of Gynaecology and Physiopathology of Human Reproduction starting from January 2000 and stored at the Operative Unit of Pathological Anatomy and Histology. Samples fixed in neutral buffered formalin and paraffin added at 50°C will be analysed by repeating histological examination and performing immunohistochemistry for BAG3. All analyses will be performed blinded to the clinical data of the patients and the results of the original examinations. No patients will be examined ex novo, as only paraffin-embedded tissue samples obtained at the time of the initial diagnosis will be analysed.
Expression of BAG3
Expression of BAG3 in patients diagnosed with precancerous lesions of the cervix
Correlation between BAG3 expression and the degree of dysplasia of cervical lesions
Correlation between BAG3 expression and the degree of dysplasia of cervical lesions
Evolution of bag3 expression over time
Evolution of BAG3 expression over time in patients with cervical biopsies/concussions afterwards
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