Evaluation of the Effectiveness of Virtual Reality Self-rehabilitation in the Treatment of Facial Paralysis and Synkinesis

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire, Amiens

About this trial

Peripheral facial palsy affects 15 to 40 people per 100,000 inhabitants and induces important functional and social repercussions. Synkinesis is a frequent after-effect of facial palsy recovery, consisting of involuntary facial spasms that disturb the gestural harmony and can go as far as a painful hypertonic spasm. More than 55% of patients recovering from facial palsy will develop transient or permanent synkinesis. These facial hypertonias have two main causes: imperfect axonal regeneration, which is all the more important as the damage is proximal, and hyperexcitability of the facial nerve nucleus due to a lack of central control. Management is therefore essential for the functional restoration of the face, especially since synkinesis do not evolve spontaneously. The main treatments are currently botulinum toxin injection, acting on the motor plate, and functional rehabilitation, consisting on local muscle relaxation and central motor control work. In recent years, therapies based on biofeedback and acting on central motor control have shown interesting results, and technological advances in virtual reality have made it possible to deepen this treatment in patients suffering from stroke, limb trauma or Parkinson's disease. In this project, the investigators evaluate the contribution of virtual reality to the management of facial palsy, and hypothesize that self-rehabilitation using this technology will improve motor control of the skin muscles and reduce complications related to their hypertonia such as synkinesis.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patient with recent onset peripheral facial palsy (≤ 12 months).

Patient with peripheral facial palsy of grade ≥ III on the House & Brackmann score

Patient of legal age (≥ 18 years)

Patient with appropriate information and informed consent

Disqualifiers

Patient with central facial palsy

Patient with peripheral facial palsy of > 12 months onset

Patient with peripheral facial palsy of grade < III House & Brackmann score

Patient who has previously undergone palliative surgery

Trial design

Design model

Parallel

Treatments tested in this trial

  • massages

    Other intervention

    The experimental rehabilitation protocol includes massages

  • motor stimulation and stretching

    Other intervention

    motor stimulation and stretching

  • virtual reality

    Other intervention

    Patient watches an avatar of his face performing different movements on a screen, and will have to imagine performing these movements without actually doing them.

Treatment groups

100 Participants
are divided into 2 treatment groups
Group A: Experimental armExperimental treatment 3 interventions
Group B: Control armActive comparator 2 interventions

Trial outcomes

Primary outcomes

1

variation of number of involuntary facial spasm between both groups of patients

variation of synkinesis in patients with recent onset (≤ 12 months) peripheral facial palsy compared with the conventional rehabilitation protocol

Time frame
12 months

Secondary outcomes

Other outcomes

Sponsors and contacts

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Centre Hospitalier Universitaire, Amiens

Lead sponsor

University Hospital, Rouen

Collaborator