Evaluation of the Effects of Laughter Yoga
ConditionMultiple Sclerosis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorFirat University
About this trial
This randomized controlled study aims to evaluate the effects of laughter yoga on pain intensity, fatigue, and beta-endorphin levels in patients with Multiple Sclerosis. Laughter yoga, a complementary therapy combining breathing exercises and laughter techniques, may help improve symptom management and psychological well-being in individuals with MS.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
• Being over 18 years old
Being able to communicate adequately
Volunteering to participate in the research
Disqualifiers
Unwillingness to participate in the study
Trial design
Design model
Parallel
Treatments tested in this trial
Laughter Yoga
BehavioralA complementary intervention including breathing exercises, stretching, relaxation techniques, and laughter exercises applied to patients with Multiple Sclerosis.
Treatment groups
72 Participants
are divided into 2 treatment groupsGroup A: Experimental GroupExperimental treatment 1 intervention
Group B: Control GroupNo intervention 0 interventions
Trial outcomes
Primary outcomes
1
Change in pain intensity measured by Visual Analog Scale (VAS) at [time point]
Pain intensity will be assessed using the Visual Analog Scale (VAS), a 10 cm scale ranging from 0 (no pain) to 10 (worst imaginable pain). Participants will indicate their pain level by marking on the scale, and the score will be determined by measuring the distance in centimeters or millimeters.
Time frame
Baseline and week 4Secondary outcomes
1
Fatigue Level
Fatigue severity will be assessed using the Fatigue Severity Scale (FSS), a 9-item questionnaire evaluating fatigue over the past month. Each item is scored on a scale of 0 to 7, with higher scores indicating greater fatigue severity. The Turkish validity and reliability study was conducted by Armutlu et al. in 2007. A change of 0.45 points is considered clinically meaningful.
Time frame
1 month2
Change in plasma beta-endorphin levels measured by ELISA at baseline and week 4
Plasma beta-endorphin levels will be measured using an ELISA method. Blood samples will be collected from participants in the intervention group before and after laughter yoga sessions at week 1 and week 4, and from the control group at week 1 and week 4. Samples will be centrifuged, and serum will be stored at -80°C until analysis. Beta-endorphin concentrations will be determined using a commercially available ELISA kit.
Time frame
Baseline and week 4Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov