About this trial
In interstitial lung disease (ILD), the extent of ILD on chest computed tomography (CT) is recognized as an important prognostic factor. Automated tools are now available to quantify ILD, but there is a lack of data on the reproducibility of this measurement and therefore its accuracy.
Therefore, the purpose of this study is to evaluate the variability of automated ILD quantification on chest CT. Reproducibility will be assessed by repeating chest CT scans and using different tools to measure the extent of disease.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥ 18 years
Known interstitial lung disease as part of idiopathic pulmonary fibrosis or connective tissue disease
Followed in one of the participating hospitals
Requiring a chest CT as part of a scheduled assessment
Disqualifiers
Acute exacerbation of ILD
Pregnancy
Inability to hold an apnea for 10 seconds
Patients in the exclusion period after a previous research
Trial design
Single group
Treatments tested in this trial
Chest CT
Diagnostic testRepeated chest CT for automated ILD quantification
Treatment groups
Trial outcomes
Primary outcomes
Automated Interstitial Lung Disease (ILD) quantification
Reproducibility of ILD quantification on chest CT (as a percentage of lung volume) between two successive scan acquisitions.
Secondary outcomes
Automated Interstitial Lung Disease (ILD) quantification
Reproducibility of disease extent measured with different software on the same acquisition
Lung volume
Reproducibility of total lung volume measured on the scanner between two successive acquisitions
Automated Interstitial Lung Disease (ILD) quantification
Reproducibility of disease extension between the two scan acquisitions depending on the disease (idiopathic pulmonary fibrosis or PID secondary to connective tissue disease).
Sponsors and contacts
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Assistance Publique - Hôpitaux de Paris
Lead sponsor
URC-CIC Paris Descartes Necker Cochin
Collaborator