Evaluation of the Reproducibility of the Automated Measurement of the Extent of ILD on Chest CT

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAssistance Publique - Hôpitaux de Paris

About this trial

In interstitial lung disease (ILD), the extent of ILD on chest computed tomography (CT) is recognized as an important prognostic factor. Automated tools are now available to quantify ILD, but there is a lack of data on the reproducibility of this measurement and therefore its accuracy.

Therefore, the purpose of this study is to evaluate the variability of automated ILD quantification on chest CT. Reproducibility will be assessed by repeating chest CT scans and using different tools to measure the extent of disease.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 18 years

Known interstitial lung disease as part of idiopathic pulmonary fibrosis or connective tissue disease

Followed in one of the participating hospitals

Requiring a chest CT as part of a scheduled assessment

Disqualifiers

Acute exacerbation of ILD

Pregnancy

Inability to hold an apnea for 10 seconds

Patients in the exclusion period after a previous research

Trial design

Design model

Single group

Treatments tested in this trial

  • Chest CT

    Diagnostic test

    Repeated chest CT for automated ILD quantification

Treatment groups

150 Participants
are divided into 1 treatment group
Group A: Patients with interstitial lung diseaseExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Automated Interstitial Lung Disease (ILD) quantification

Reproducibility of ILD quantification on chest CT (as a percentage of lung volume) between two successive scan acquisitions.

Time frame
Day of inclusion

Secondary outcomes

1

Automated Interstitial Lung Disease (ILD) quantification

Reproducibility of disease extent measured with different software on the same acquisition

Time frame
Day of inclusion
2

Lung volume

Reproducibility of total lung volume measured on the scanner between two successive acquisitions

Time frame
Day of inclusion
3

Automated Interstitial Lung Disease (ILD) quantification

Reproducibility of disease extension between the two scan acquisitions depending on the disease (idiopathic pulmonary fibrosis or PID secondary to connective tissue disease).

Time frame
Day of inclusion

Other outcomes

Sponsors and contacts

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Assistance Publique - Hôpitaux de Paris

Lead sponsor

URC-CIC Paris Descartes Necker Cochin

Collaborator