Evaluation of the Use of the FUR to Quantify Tumor Glucose Consumption in Oncologic PET
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAcademisch Ziekenhuis Maastricht
About this trial
The goal of this study is to evaluate the use of new method to quantify the amount of sugar a tumor consumes using PET/CT. The main questions it aims to answer are:
* Is the new quantification method superior with respect to the method currently used in the clinic? * Does the new quantification method provide accurate assessment of the sugar consumption of tumours?
Participants who will undergo a standard care FDG PET/CT scan will in additional receive a dynamic PET/CT scan prior to the standard care scan. In addition blood samples will be drawn at three time points during the examination.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients who receive an 18F FDG PET/CT scan as part of standard care
Be competent and be 18 years of age or older
Disqualifiers
Diabetes (fasted blood glucose > 7 mmol/L)
Not fasted > 4 hours
Physical exercise within 24 hours
Earlier treatment for carcinoma with radio/chemo-therapy
Trial population
A total of 30 oncologic patients who will receive an 18F-FDG PET/CT scan as part of standard care will participate in this study. Therefore, recruitment of participants will take place among oncologic patients who are referred to the department of radiology and nuclear medicine of the MUMC+ for an 18F-FDG PET/CT examination.
Trial design
Design model
Case-only
Time perspective
Prospective
Treatments tested in this trial
FDG PET/CT
Diagnostic testBesides the standard care FDG PET/CT examination, subjects receive a dynamic whole body PET/CT examination.
Treatment groups
30 Participants
are divided into 1 treatment groupGroup A: Oncologic patients1 intervention
Trial outcomes
Primary outcomes
1
Superiority of the FUR compared to the SUV
The correlation between the fractional uptake rate (FUR) and the metabolic glucose consumption (Km) will be compared to the correlation between the standardized uptake value (SUV) and Km
Time frame
Time of PET examinationSecondary outcomes
1
FUR validation to quantify tumour metabolic activity
Comparison between the assessment of the tumour metabolic activity as measured by the FUR vs traditional Patlak method
Time frame
Time of PET examination2
Impact of patient-specific input function
The impact of the use of a patient-specific input function is investigated compared to the use of a (scaled) population-based input function on the accuracy of Km assessment using the FUR
Time frame
Time of PET examinationSponsors and contacts
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Source ClinicalTrials.gov