About this trial
The goal of modern neurooncological surgery is to obtain maximum tumor resection while preserving neurological function. Parietal lobe gliomas often cause attention deficits (hemineglect) that are difficult to differentiate from other deficits. This study aims to evaluate the extent and variation over time of visuo-spatial deficits in patients undergoing surgical removal of parietal lobe gliomas. This will help characterize the cognitive profile of these patients to identify personalized treatment and rehabilitation paths.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients >18 years old
Patients must understand the Italian Language
Patients with suspected parietal lobe glioma
Disqualifiers
Tumor site other than parietal lobe.
Patients who cannot undergo surgical resection (stereotactic/open biopsy).
Patients who received a previous chemotherapy and/or radiotherapy treatment.
Patients with a history of intracranial mass lesion or traumatic brain injury.
Trial population
Patients with suspected parietal lobe glioma
Trial design
Cohort
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Change in Visuospatial Deficit Prevalence
Prevalence of patients with a score below the cut-off in specific neuropsychological tests for visuo-spatial aspects (Line Bisection, Bell/Letter Cancellation, Apple Cancellation, Fluff Test) and the extent of change compared to baseline.
Secondary outcomes
Association with Radiological Data
Correlation between visuo-spatial deficit scores and MRI data (FLAIR volume, T1 contrast, necrosis, localization).
Association with Clinical-Demographic Data
Correlation between visuo-spatial scores and hemispheric dominance, age, sex, and education.
Association with Performance Status
Correlation between visuo-spatial scores and Karnofsky Performance Status (KPS).
Association with Histological/Molecular Data
Correlation between visuo-spatial scores and tumor grade, histological and molecular features.
Sponsors and contacts
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