Evaluation of the Variation Over Time of Visuospatial Deficit in Patients With Parietal Lobe Glioma

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

About this trial

The goal of modern neurooncological surgery is to obtain maximum tumor resection while preserving neurological function. Parietal lobe gliomas often cause attention deficits (hemineglect) that are difficult to differentiate from other deficits. This study aims to evaluate the extent and variation over time of visuo-spatial deficits in patients undergoing surgical removal of parietal lobe gliomas. This will help characterize the cognitive profile of these patients to identify personalized treatment and rehabilitation paths.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients >18 years old

Patients must understand the Italian Language

Patients with suspected parietal lobe glioma

Disqualifiers

Tumor site other than parietal lobe.

Patients who cannot undergo surgical resection (stereotactic/open biopsy).

Patients who received a previous chemotherapy and/or radiotherapy treatment.

Patients with a history of intracranial mass lesion or traumatic brain injury.

Trial population

Patients with suspected parietal lobe glioma

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Change in Visuospatial Deficit Prevalence

Prevalence of patients with a score below the cut-off in specific neuropsychological tests for visuo-spatial aspects (Line Bisection, Bell/Letter Cancellation, Apple Cancellation, Fluff Test) and the extent of change compared to baseline.

Time frame
Baseline (pre-surgery), 3-4 months post-surgery, 6 months post-surgery.

Secondary outcomes

1

Association with Radiological Data

Correlation between visuo-spatial deficit scores and MRI data (FLAIR volume, T1 contrast, necrosis, localization).

Time frame
Up to 6 months post-surgery
2

Association with Clinical-Demographic Data

Correlation between visuo-spatial scores and hemispheric dominance, age, sex, and education.

Time frame
Up to 6 months post-surgery.
3

Association with Performance Status

Correlation between visuo-spatial scores and Karnofsky Performance Status (KPS).

Time frame
Time Frame: Up to 6 months post-surgery.
4

Association with Histological/Molecular Data

Correlation between visuo-spatial scores and tumor grade, histological and molecular features.

Time frame
Up to 6 months post-surgery.

Other outcomes

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