To evaluate the degree of acute and long-term intestinal, urinary and vaginal toxicity, and the impact on sexual activity of an accelerated fractionation of high dose rate interventional radiotherapy (IRT-HDR) in patients with locally advanced cervical cancer (IB2 - VA, N+/-).
Age ≥18 years
ECOG 0-2
Histological diagnosis of squamous carcinoma and/or adenocarcinoma of the uterine cervix
FIGO IB2 Stadium - IVA (staging 20018)
Age <18 years
PS >2
Previous cancer in the last 10 years
Previous radiation treatment in the region of interest
Patients with locally advanced cervix cancer
Cohort
Prospective
Interventional Radiotherapy
RadiationThe patients will undergo four IRT fractions in one week
Acute and late gastrointestinal toxicity
Acute and late toxicities will evaluated with CTCAE scale to analyze the safety of accelerated interventional radiotherapy
Acute and late urinary toxicity
Acute and late urinary toxicities will evaluated with CTCAE scale to analyze the safety of accelerated interventional radiotherapy
Sexual activity
Sexual activity will evaluated with CTCAE scale to analyze the safety of accelerated interventional radiotherapy
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