Evaluation of Updated Procedure for Management of Refractory Out-of-hospital Cardiac Arrests

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorCentral Hospital, Nancy, France

About this trial

ECPR is a technique that has been rapidly developed in many cardiac arrest specialized centers In 2013, a specific management protocol was developed for patients in refractory out-of-hospital cardiac arrest around Nancy, France. To select patients with the best prognosis, the inclusion criteria defined were strict. This led to an over-selection of patients and a significant reduction in the number of eligible patients. A balance needed to be struck between over-selecting patients and maintaining the expertise of medical and paramedical teams in the field. In addition, it has also been shown that ECPR also increases the number of organs and transplants.

In February 2024, the criteria for inclusion in the protocol were redefined to include any witnessed non-traumatic cardiac arrest, whatever the initial rhythm. This simplification should enable more patients to be included in the procedure.

The aim of the study is to assess the patient's outcome

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Out-of-hospital cardiac arrest

enrolled in the ECPR program

18 years old or more

Low-flow estimated <60minutes

Disqualifiers

traumatic cardiac arrest

major comorbidities

Trial population

All patients presenting with refractory out-of-hospital cardiac arrest and enrolled in the ECPR program in Nancy, France. Inclusion criteria for the ECPR program are the following: * Age: 18-65 years * No major comorbidity * Witnessed non traumatic cardiac arrest * Low-flow to ECPR estimated of less than 60 minutes

Trial design

Design model

Case-only

Time perspective

Retrospective

Treatments tested in this trial

  • ECPR for out-of-hospital cardiac arrest

    Other intervention

    Patient with out-of-hospital cardiac arrest enrolled in the ECPR protocol

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Survival

Survival rate of patients enrolled in the protocol

Time frame
90 days after cardiac arrest

Secondary outcomes

1

Delays

Delay between cardiac arrest and ECPR implementation

Time frame
From event to implementation of ECMO, in minutes, Up to 180 minutes
2

Neurological outcome

Evaluation of neurological outcome of survivors after cardiac arrest using the Rankin score

Time frame
30 days and 90 days after cardiac arrest

Other outcomes

Sponsors and contacts

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This trial is not recruiting at the moment. You can still explore other options: