Evaluation of Volume and Electrolyte Balance in Hyponatremia Treatment - a Prospective Observational Trial

ConditionNon-hypervolemic Hyponatremia

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorUniversity of Cologne

About this trial

To assess quantitatively the evolution over time of electrolyte-free water clearance and electrolyte mass balance in patients with non-hypervolemic hypotonic hyponatremia

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adult patients ≥ 18 years

Hypotonic hyponatremia

glucose-corrected plasma sodium <130 mmol/l

serum osmolality <280 mosmol/kg or lack of signs of non-hypotonic hyponatremia

Disqualifiers

Signs of extracellular volume expansion

Patients with liver cirrhosis and severe liver damage AST/ALT>3xULN, AP>6xULN, Bilirubin ≥ 3mg/dl

Patients with heart failure

Patients on dialysis and/or patients with oliguric renal impairment and plasma creatinine ≥ 3mg/dl

Trial population

Patients with non-hypervolemic hyponatremia

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Patients
Other intervention
Patients will get study-specific measurements within first 5 days of standard of care treatment of hyponatremia or until discharge

Treatment groups

50 Participants

are divided into 1 treatment group

Group A: Patients1 intervention

Trial outcomes