Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-80
SponsorKorea University Anam Hospital
About this trial
The correlation of coronary microvascular function and body composition with cardiopulmonary exercise capacity will be assessed in patients with heart failure with preserved ejection fraction.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 20 to 80
Typical/atypical chest pain or ischemic symptoms including dyspnea
No significant coronary artery stenosis (>50% stenosis) in coronary angiography or computed tomography
Left ventricular ejection fraction ≥50%
Disqualifiers
More than moderate valvular heart disease
Congenital heart disease
Chronic renal failure (estimated glomerular filtration rate <30 ml/min/1.73m2) or end-stage renal failure undergoing hemodialysis or peritoneal dialysis
Asthma, chronic obstructive pulmonary disease and primary pulmonary hypertension
Trial design
Design model
Single group
Treatments tested in this trial
Adenosine stress echocardiography with the evaluation of coronary artery blood flow
Diagnostic testThe color Doppler flow of distal left anterior descending artery will be examined from the modified apical four-chamber view in the anterior interventricular groove. In regard to body composition analysis, Using InBody S10, impedance is measured in 6 frequency bands (1 kilohertz (kHz), 5 kHz, 50 kHz, 250 kHz, 500 kHz, 1000 kHz) for each of 5 parts (right plate, left arm, torso, right leg, left leg). Reactance is measured in 3 frequency bands (5 kHz, 50 kHz, 250 kHz for each of 5 parts (right arm, left arm, torso, right leg, left leg). By treadmill exercise test with modified Bruce protocol or bicycle ergometer for patients with orthopedic problems, maximal oxygen consumption (VO2 max) will be measured using the exhalation gas analysis.
Treatment groups
100 Participants
are divided into 1 treatment groupGroup A: Heart failure with preserved ejection fractionOther 1 intervention
Trial outcomes
Primary outcomes
1
Correlation of coronary blood flow with cardiopulmonary exercise capacity
Coronary blood flow is assessed by coronary flow reserve (CFR), which is defined as peak to baseline mean diastolic velocity of coronary flow. In regard to cardiopulmonary exercise capacity, maximal oxygen consumption (VO2max) will be assessed.
Time frame
up to day 142
Correlation of body composition with cardiopulmonary exercise capacity
In body composition analysis, skeletal muscle mass and body fat mass will be assessed. In regard to cardiopulmonary exercise capacity, maximal oxygen consumption (VO2max) will be assessed.
Time frame
up to day 14Sponsors and contacts
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Source ClinicalTrials.gov