EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation

ConditionParoxysmal Atrial Fibrillation

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorVirginia Commonwealth University

About this trial

Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥18 years

Diagnosis of paroxysmal AF

Left ventricular ejection fraction ≥50%

Scheduled for catheter ablation

Disqualifiers

Persistent or permanent AF

Prior ablation (catheter based or surgical) for AF

Significant sinus node dysfunction

Implanted pacemaker or defibrillator

Trial population

In patients undergoing catheter ablation for paroxysmal AF, reduction or elimination of arrhythmia burden will result in favorable LA reverse remodeling - which will result in improved LA reservoir function reserve during exercise, thereby augmenting LV stroke volume reserve during exercise.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Self- Report Evaluation-Duke Activity Status Index
Behavioral
Complete the Self- Report Evaluation-Duke Activity Status Index
Self- Report Evaluation Atrial Fibrillation Effect on Quality of Life Questionnaire
Behavioral
Complete the Self- Report Evaluation, Atrial Fibrillation Effect on Quality of Life Questionnaire
Cardiopulmonary exercise test (CPET)
Diagnostic test
Cardiopulmonary exercise test (CPET)
Transthoracic echocardiogram
Diagnostic test
Transthoracic echocardiogram at rest and immediately following peak exercise during CPET
Ambulatory cardiac rhythm assessment
Diagnostic test
Ambulatory cardiac rhythm assessment
Cardiovascular magnetic resonance (CMR)
Diagnostic test
Cardiovascular magnetic resonance (CMR) study at rest and during two stages of submaximal exercise (ExeCMR)

Treatment groups

50 Participants

are divided into 1 treatment group

Group A: Patients under going catheter ablation6 interventions

Trial outcomes

Primary outcomes

Change in LA reservoir function reserve at submaximal exercise after catheter ablation in patients with paroxysmal AF.

Change in LA reservoir volume reserve from baseline to follow up, change in left ventricular (LV) stroke volume reserve from baseline to follow up, correlation between changes in LA reservoir volume reserve and changes in LV stroke volume reserve. Therefore the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation.

Time frame