Health TrialsbyHealthPanel

Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction

ConditionHeart Failure With Preserved Ejection Fraction
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorMayo Clinic

About this trial

The purpose of this study is to internally validate low-field Ex-CMR as a noninvasive tool for diagnosing, phenotyping, and risk stratifying HFpEF in patients with exertional dyspnea.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Informed consent obtained

HFpEF (cardiologist-adjudicated diagnosis as verified by PI, EF≥50%)

Non-cardiac dyspnea (patients have dyspnea but were found on invasive exercise testing not to have HFpEF).

Healthy volunteers with no history of dyspnea or effort intolerance.

Disqualifiers

Contraindication for low-field CMR, as indicated in MRI safety screening checklist (Research Document #1)

Patient inability or unwillingness to undergo Ex-CMR

Cardiac implants, mechanical or biological valve, causing artifacts that compromise the quality of data

Hospitalization for heart failure in the preceding 30 days.

Trial population

Participants will be identified from Mayo Clinic Cardiac Cath lab appointment lists.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Exercise Cardiovascular Magnetic Resonance

    Diagnostic test

    Exercise Cardiovascular Magnetic Resonance is a non-invasive imaging technique that combines cardiovascular magnetic resonance (CMR) with exercise stress testing.

Treatment groups

400 Participants
are divided into 3 treatment groups
Group A: HFpEF (Heart Failure with Preserved Ejection Fraction)1 intervention
Group B: Non-cardiac dyspnea1 intervention
Group C: Healthy Volunteers1 intervention

Trial outcomes

Primary outcomes

1

Number of heart failure hospitalizations

Number of heart failure hospitalizations will be determined by the number of patients admitted to the hospital due to heart failure complications.

Time frame
Baseline
2

Number of cardiac deaths

The number of cardiac deaths will include all patients whose death is attributable to a cardiac cause.

Time frame
Baseline

Secondary outcomes

1

Number of deaths

The number of deaths will include all patient deaths, regardless of cause.

Time frame
Baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Mayo Clinic

Lead sponsor

Source ClinicalTrials.gov
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