Health TrialsbyHealthPanel

Exercise Effects on the Neurobiology Underlying Stress-related Eating Behaviors in Veterans

ConditionsOverweight/ObesityStress
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorVA Office of Research and Development

About this trial

The purpose of this study is to learn more about how common lifestyle interventions, such as exercise, affect how our brains respond to performing thinking tasks and to viewing pictures of foods and various other objects. The investigators are also interested in how changes in hormones that might be different in men and women could affect how lifestyle interventions change these brain responses.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Veteran

Body mass index (BMI) of 25 or greater

Physically inactive

Able to attend study visits in person in Aurora, CO

Disqualifiers

Currently pregnant

History of bariatric surgery

Current eating disorder

Current treatment with appetite-altering medications (e.g., glucagon-like peptide-1 (GLP-1) agonists)

Trial design

Design model

Parallel

Treatments tested in this trial

  • Exercise

    Behavioral

    12 weeks of aerobic exercise, with 4 sessions per week.

Treatment groups

132 Participants
are divided into 2 treatment groups
Group A: ExerciseExperimental treatment 1 intervention
Group B: Usual activityNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Percent change in blood oxygen level dependent (BOLD) response to visual food cues as measured by functional magnetic resonance imaging (fMRI)

Percent change in blood oxygen level dependent (BOLD) response from baseline to after the 12-week intervention period while viewing visual food cues. The primary contrast of interest is the comparison of high-calorie food images to nonfood object images.

Time frame
Baseline, 12 weeks
2

Change in serum cortisol response to counting task

Change from baseline to after the 12-week intervention period in serum cortisol levels (micrograms per deciliter (mcg/dL)) throughout a counting task involving mental math (measured as area under the curve).

Time frame
Baseline, 12 weeks

Secondary outcomes

1

Change in heart rate response to counting task

Change from baseline to after the 12-week intervention period in heart rate (measured by photoplethysmograph; aggregated in 1 min intervals) throughout a counting task involving mental math (measured as area under the curve).

Time frame
Baseline, 12 weeks

Other outcomes

1

Change in percent body fat

Change in percent body fat, as measured by dual-energy x-ray absorptiometry, from baseline to after the 12-week intervention period.

Time frame
Baseline, 12 weeks
2

Percent change in body weight

Percent change in body weight (kilograms) from baseline to after the 12-week intervention period.

Time frame
Baseline, 12 weeks

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

VA Office of Research and Development

Lead sponsor

Source ClinicalTrials.gov
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