Exercise Magnetic Resonance Imaging in Patients With Obesity Associated Heart Failure
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity Medical Center Groningen
About this trial
To aim of the EXPOSURE study is to investigate the effects of epicardial fat on cardiac function, pericardial constraint and pulmonary artery vasodilatation using cardiac magnetic resonance (CMR) imaging at rest and during exercise stress testing in patients with HFpEF.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Signs and symptoms of HF according to the Europeans Society of Cardiology guideline.
LV ejection fraction ≥40%.
HFA-PEFF score ≥5 or HFA-PEFF score 2-4 in combination with positive stress test (Figure 1).
>18 years of age
Disqualifiers
Body weight >140 kg
Atrial fibrillation or other significant arrhythmia during the assessment
Contraindications for CMR (e.g. claustrophobia, implanted cardiac devices)
Myocardial infarction, percutaneous coronary intervention or coronary artery bypass graft <3 months or untreated severe obstructive coronary artery stenosis
Trial population
A cohort of 50 patients with HFpEF, in which the effects of epicardial fat on cardiac function, pericardial constraint and pulmonary artery vasodilatation will be tested using cardiac magnetic resonance (CMR) imaging at rest and during exercise stress testing.
Trial design
Design model
Cohort
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Ventricular interdependence
the effect of epicardial fat on ventricular interdependence at peak exercise
Time frame
BaselineSecondary outcomes
1
VO2-max
the effect of epicardial fat on VO2-max at peak exercise
Time frame
Baseline2
LV/RV diastolic strain rate
the effect of epicardial fat on ventricular diastolic strain rate measured on echocardiography at peak exercise
Time frame
Baseline3
slope of early LV/RV filling
the effect of epicardial fat on slope of early ventricular filling measured on echocardiography at peak exercise
Time frame
Baseline4
left and right atrial reservoir strain
the effect of epicardial fat on atrial emptying fraction measured on echocardiography at peak exercise
Time frame
BaselineSponsors and contacts
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Source ClinicalTrials.gov