Health TrialsbyHealthPanel

Exercise Response in Humans With Obesity

ConditionObese
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20-45
SponsorMayo Clinic

About this trial

This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Obese men and women ≥ 20 and ≤ 45 years of age.

Disqualifiers

Diabetes or fasting plasma glucose >126 mg/dL

Anemia (female subjects hemoglobin of <11 g/dl and male subjects hemoglobin <12 g/dl)

Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)

Renal failure (serum creatinine > 1.5mg/dl)

Trial population

Men and women ages 20-45 years with Body Mass Index 20-40

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Treadmill Test

    Diagnostic test

    Measurement of whole-body fitness level. Walking or running on a treadmill and breathing into a machine that measures oxygen level during test. Heart rhythm is continuously monitored during exercise using an electrocardiogram (ECG).

  • Strength Test

    Diagnostic test

    Measure the strength of leg muscles by kicking against a machine with resistance.

  • Dual-Energy X-Ray Absorptiometry

    Diagnostic test

    Body composition measurement.

  • Muscle Biopsy

    Procedure/Surgery

    Obtain a small piece of muscles from the upper part of the legs

  • Fat Biopsy

    Procedure/Surgery

    Fat sample taken from abdomen

  • Resting Energy Expenditure

    Diagnostic test

    Measured by indirect calorimetry. Measures how much energy the body uses at rest by placing a special plastic dome over the head while resting quietly for 30 minutes. Measures oxygen breathed in and carbon dioxide breathed out.

  • Magnetic resonance imaging

    Diagnostic test

    MRI on upper leg to look at fat and muscle

Treatment groups

120 Participants
are divided into 2 treatment groups
Group A: Lean Group7 interventions
Group B: Obese Group7 interventions

Trial outcomes

Primary outcomes

1

Change in muscle protein synthesis

Skeletal muscle protein synthesis will be measured from the rate of incorporation of infused amino acids measured by mass spectrometry.

Time frame
Baseline, post-exercise approximately 8 hours

Secondary outcomes

1

Change in mRNA expression of exercise responsive genes

Measure messenger ribonucleic acids (mRNAs) expression on exercise responsive genes

Time frame
Baseline, post-exercise approximately 8 hours
2

Change in expression and activation (phosphorylation) of signaling proteins

Phosphorylation is a common mechanism for the regulation of receptor function

Time frame
Baseline, post-exercise approximately 8 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Mayo Clinic

Lead sponsor

Source ClinicalTrials.gov
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