This study will compare the effects on cardiorespiratory fitness (CRF) of aerobic exercise in different amounts (number of minutes/session) over different periods of time (number of weeks). Aerobic exercise is physical activity of light-to-moderate intensity that uses the large muscle groups (muscles in your legs, buttocks, back, and chest) and can be performed for at least 10 minutes.
The researchers will study the effects of different exercise programs on how well the study participants' bodies use oxygen, how well their heart pumps blood, how well their lungs function, and how healthy their blood vessels are.
Aged 21-80 years
Female
Surgically resected early stage (I-III) primary breast cancer
Age ≥ 45 with no menses for at least 2 years
Acute myocardial infarction within 3-5 days of any planned study procedures
Unstable angina
Uncontrolled arrhythmia causing symptoms or hemodynamic compromise
Recurrent syncope
Parallel
Aerobic Training
Other intervention300 min/wk for 16 weeks
Aerobic Training
Other intervention150 min/wk for 32 weeks
Aerobic Training
Other intervention300 min/wk for 32 weeks
Aerobic Training
Other intervention150 min/wk for 16 weeks
peak oxygen consumption (VO2peak; ml O2.kg-1.min) response rate
A CRF change ≥1.32 ml O2.kg-1.min-1 will be considered a response; a change \<1.32 ml O2.kg-1.min-1 will be considered a non-response.
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Memorial Sloan Kettering Cancer Center
Lead sponsor
National Cancer Institute (NCI)
Collaborator
